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Literature DB >> 872440

(2-Ethoxyethoxy)acetic acid: an unusual compound found in the gas chromatographic analysis of urinary organic acids.

J P Kamerling, M Duran, L Bruinvis, D Ketting, S K Wadman, C J de Groot, F A Hommes.

Abstract

An unknown acidic compound was detected in a number of urine samples from patients with a suspected metabolic disorder and some patients treated with chemotherapy. The structure of this compound has been characterized as (2-ethoxyethoxy)acetic acid, using a gas chromatography/mass spectrometry/computer system. The authentic compound was synthesized and compared with the unknown. Urinary (2-ethoxyethoxy)acetic acid is assumed to be formed endogenously from an exogenous precursor, probably 2-(2-ethoxyethoxy)ethanol.

Entities: Chemical Disease Species

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Year: 1977 PMID： 872440 DOI： 10.1016/0009-8981(77)90246-7

Source DB: PubMed Journal: Clin Chim Acta ISSN： 0009-8981 Impact factor: 3.786

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Cited

10 in total

1. Leigh's disease with decreased activities of pyruvate carboxylase and pyruvate decarboxylase.

Authors: J P Van Biervliet; M Duran; S K Wadman; J F Koster; A van Rossum
Journal: J Inherit Metab Dis Date: 1980 Impact factor: 4.982

2. Dietary treatment and biochemical studies on a neonatal case of propionyl-CoA carboxylase deficiency.

Authors: J A DelValle; B Merinero; A Jiménez; M J García; M Ugarte; F Omeñaca; G Neustadt; J Quero
Journal: J Inherit Metab Dis Date: 1982 Impact factor: 4.982

3. Two sisters with isovaleric acidaemia, multiple attacks of ketoacidosis and normal development.

Authors: M Duran; F J van Sprang; J G Drewes; L Bruinvis; D Ketting; S K Wadman
Journal: Eur J Pediatr Date: 1979-06-28 Impact factor: 3.183

4. Deranged isoleucine metabolism during ketotic attacks in patients with methylmalonic acidaemia.

Authors: M Duran; L Bruinvis; D Ketting; S K Wadman
Journal: J Inherit Metab Dis Date: 1978 Impact factor: 4.982

5. Biotin dependent multiple carboxylase deficiency presenting as a congenital lactic acidosis.

Authors: A Munnich; J M Saudubray; A Cotisson; F X Coudĕ; H Ogier; C Charpentier; C Marsac; G Carrĕ; M Bourgeay-Causse; J Frĕzal
Journal: Eur J Pediatr Date: 1981-10 Impact factor: 3.183

6. Diagnosis of isovaleric acidaemia by tandem mass spectrometry: false positive result due to pivaloylcarnitine in a newborn screening programme.

Authors: J E Abdenur; N A Chamoles; A E Guinle; A B Schenone; A N Fuertes
Journal: J Inherit Metab Dis Date: 1998-08 Impact factor: 4.982

(2-Ethoxyethoxy)acetic acid: an unusual compound found in the gas chromatographic analysis of urinary organic acids.

1. Leigh's disease with decreased activities of pyruvate carboxylase and pyruvate decarboxylase.

2. Dietary treatment and biochemical studies on a neonatal case of propionyl-CoA carboxylase deficiency.

3. Two sisters with isovaleric acidaemia, multiple attacks of ketoacidosis and normal development.

4. Deranged isoleucine metabolism during ketotic attacks in patients with methylmalonic acidaemia.

5. Biotin dependent multiple carboxylase deficiency presenting as a congenital lactic acidosis.

6. Diagnosis of isovaleric acidaemia by tandem mass spectrometry: false positive result due to pivaloylcarnitine in a newborn screening programme.

7. L-2-Hydroxyglutaric aciduria: an inborn error of metabolism?

8. Glutaric aciduria type II: treatment with riboflavine, carnitine and insulin.

9. Analyses of ethylene glycol monoalkyl ethers and their proposed metabolites in blood and urine.

10. Pulmonary and percutaneous absorption of 2-propoxyethyl acetate and 2-ethoxyethyl acetate in beagle dogs.