Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

Literature DB >> 8723724

A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

M A Ansari-Lari¹, D M Muzny, J Lu, F Lu, C E Lilley, S Spanos, T Malley, R A Gibbs.

Abstract

The genomic sequence of the human CD4 gene and its neighboring region, located at chromosome 12p13, was generated using the large-scale shotgun sequencing strategy. A total of 117 kb of genomic sequence and approximately 11 kb of cDNA sequence were obtained. Six genes, including CD4, triosephosphate isomerase, B3 subunit of G proteins (GNB3), and ubiquitin isopeptidase T (ISOT), with known functions, and two new genes with unknown functions were identified. Using a battery of strategies, the exon/intron boundaries, splice variants, and tissue expression patterns of the genes were determined. Various computer software was utilized for analyses of the DNA and amino acid sequences. The results of the analyses and sequence-based strategies for gene identification are discussed.

Entities: Gene Species

Mesh：

Substances：

Year: 1996 PMID： 8723724 DOI： 10.1101/gr.6.4.314

Source DB: PubMed Journal: Genome Res ISSN： 1088-9051 Impact factor: 9.043

Keyword Cloud
Cited

23 in total

1. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

Authors: Tao Xie; Lee Rowen; Begoña Aguado; Mary Ellen Ahearn; Anup Madan; Shizhen Qin; R Duncan Campbell; Leroy Hood
Journal: Genome Res Date: 2003-12 Impact factor: 9.043

2. Analysis of the quality and utility of random shotgun sequencing at low redundancies.

Authors: J Bouck; W Miller; J H Gorrell; D Muzny; R A Gibbs
Journal: Genome Res Date: 1998-10 Impact factor: 9.043

Review 3. Computational methods for exon detection.

Authors: J M Claverie
Journal: Mol Biotechnol Date: 1998-08 Impact factor: 2.695

4. Autosomal dominant hypophosphatemic rickets is linked to chromosome 12p13.

Authors: M J Econs; P T McEnery; F Lennon; M C Speer
Journal: J Clin Invest Date: 1997-12-01 Impact factor: 14.808

5. Sequence mapping by electronic PCR

Authors: Gregory D Schuler
Journal: Genome Res Date: 1997-05 Impact factor: 9.043

6. Retrovirus vectors bearing jaagsiekte sheep retrovirus Env transduce human cells by using a new receptor localized to chromosome 3p21.3.

Authors: S K Rai; J C DeMartini; A D Miller
Journal: J Virol Date: 2000-05 Impact factor: 5.103

A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

1. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

2. Analysis of the quality and utility of random shotgun sequencing at low redundancies.

Review 3. Computational methods for exon detection.

4. Autosomal dominant hypophosphatemic rickets is linked to chromosome 12p13.

5. Sequence mapping by electronic PCR

6. Retrovirus vectors bearing jaagsiekte sheep retrovirus Env transduce human cells by using a new receptor localized to chromosome 3p21.3.

7. Genome complexity in the coelacanth is reflected in its adaptive immune system.

8. Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.

9. Nitric oxide may inhibit neointimal hyperplasia by decreasing isopeptidase T levels and activity in the vasculature.

10. Evaluation of differentially expressed genes identified in keratoconus.