Literature DB >> 8723489

Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations.

S Merali1, K Chin, R W Grady, A B Clarkson.   

Abstract

In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of > or = 1.5 micrograms m-1 eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS-associated P.carinii pneumonia.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8723489      PMCID： PMC163314          DOI： 10.1128/AAC.40.5.1298

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

Review 1.  Prevention and treatment of pneumocystis pneumonia.

Authors:  H Masur
Journal:  N Engl J Med       Date:  1992-12-24       Impact factor: 91.245

Review 2.  Pneumocystis carinii, an opportunist in immunocompromised patients.

Authors:  M S Bartlett; J W Smith
Journal:  Clin Microbiol Rev       Date:  1991-04       Impact factor: 26.132

Review 3.  Immunopathogenesis of Pneumocystis carinii infection.

Authors:  P D Walzer
Journal:  J Lab Clin Med       Date:  1991-09

Review 4.  Why have Pneumocystis carinii trophozoites been ignored?

Authors:  J M Chatterton; A W Joss; M M Davidson; D O Ho-Yen
Journal:  J Clin Pathol       Date:  1990-04       Impact factor: 3.411

5.  Studies in desferrioxamine and ferrioxamine metabolism in normal and iron-loaded subjects.

Authors:  M R Summers; A Jacobs; D Tudway; P Perera; C Ricketts
Journal:  Br J Haematol       Date:  1979-08       Impact factor: 6.998

Review 6.  Ultrastructure of Pneumocystis carinii: a review of internal and surface characteristics.

Authors:  C W Bedrossian
Journal:  Semin Diagn Pathol       Date:  1989-08       Impact factor: 3.464

Review 7.  Iron chelation.

Authors:  C Hershko; A Pinson; G Link
Journal:  Blood Rev       Date:  1990-03       Impact factor: 8.250

8.  Deferoxamine and eflornithine (DL-alpha-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia.

Authors:  A B Clarkson; M Sarić; R W Grady
Journal:  Antimicrob Agents Chemother       Date:  1990-09       Impact factor: 5.191

9.  Suppressive effect of deferoxamine on the growth of Pneumocystis carinii in vitro.

Authors:  G A Weinberg; M M Shaw
Journal:  J Protozool       Date:  1991 Nov-Dec

10.  Response of rat model of Pneumocystis carinii pneumonia to continuous infusion of deferoxamine.

Authors:  S Merali; K Chin; R W Grady; L Weissberger; A B Clarkson
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191
View more
  1 in total

1.  Continuous axenic cultivation of Pneumocystis carinii.

Authors:  S Merali; U Frevert; J H Williams; K Chin; R Bryan; A B Clarkson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.