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Literature DB >> 8723480

Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones.

Abstract

The multiple antibiotic resistance (mar) locus in Escherichia coli consists of two divergently expressed operons (marC and marRAB), both of which contribute to the Mar phenotype. Overexpression of the marRAB operon protected E. coli against rapid cell killing by fluoroquinolones. Inactivation of the operon in mar mutants restored a wild-type bactericidal susceptibility. Both operons of the locus were required for protection from the quinolone-mediated bactericidal activity in mar locus deletion mutants. The effect was lost at high concentrations of fluoroquinolones, unlike the case for the previously described genes hipA and hipQ. The inducible mar locus appears to specify a novel antibactericidal mechanism which may play a role in the emergence of fluoroquinolone-resistant clinical E. coli isolates.

Entities: Chemical Gene Species

Mesh：

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Year: 1996 PMID： 8723480 PMCID： PMC163305 DOI： 10.1128/AAC.40.5.1266

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

1. The emergence of highly fluoroquinolone-resistant Escherichia coli in community-acquired urinary tract infections.

Authors: J M Aguiar; J Chacon; R Canton; F Baquero
Journal: J Antimicrob Chemother Date: 1992-03 Impact factor: 5.790

2. Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.

Authors: D S Black; A J Kelly; M J Mardis; H S Moyed
Journal: J Bacteriol Date: 1991-09 Impact factor: 3.490

3. Characterization of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli.

Authors: A S Seoane; S B Levy
Journal: J Bacteriol Date: 1995-06 Impact factor: 3.490

4. Active efflux of chloramphenicol in susceptible Escherichia coli strains and in multiple-antibiotic-resistant (Mar) mutants.

Authors: L M McMurry; A M George; S B Levy
Journal: Antimicrob Agents Chemother Date: 1994-03 Impact factor: 5.191

5. Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.

Authors: D S Black; B Irwin; H S Moyed
Journal: J Bacteriol Date: 1994-07 Impact factor: 3.490

6. Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli.

Authors: L Gambino; S J Gracheck; P F Miller
Journal: J Bacteriol Date: 1993-05 Impact factor: 3.490

7. A multidrug resistance regulatory chromosomal locus is widespread among enteric bacteria.

Authors: S P Cohen; W Yan; S B Levy
Journal: J Infect Dis Date: 1993-08 Impact factor: 5.226

8. Ten-year survey of quinolone resistance in Escherichia coli causing urinary tract infections.

Authors: E Pérez-Trallero; M Urbieta; D Jimenez; J M García-Arenzana; G Cilla
Journal: Eur J Clin Microbiol Infect Dis Date: 1993-05 Impact factor: 3.267

9. Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a non-plasmid-determined efflux of tetracycline.

Authors: A M George; S B Levy
Journal: J Bacteriol Date: 1983-08 Impact factor: 3.490

10. Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences.

Authors: R G Martin; J L Rosner
Journal: Proc Natl Acad Sci U S A Date: 1995-06-06 Impact factor: 11.205

27 in total

Review 1. Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Authors: K Poole
Journal: Antimicrob Agents Chemother Date: 2000-09 Impact factor: 5.191

2. Activation of multiple antibiotic resistance in uropathogenic Escherichia coli strains by aryloxoalcanoic acid compounds.

Authors: C Balagué; E G Véscovi
Journal: Antimicrob Agents Chemother Date: 2001-06 Impact factor: 5.191

3. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli.

Authors: D G White; J D Goldman; B Demple; S B Levy
Journal: J Bacteriol Date: 1997-10 Impact factor: 3.490

Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones.

1. The emergence of highly fluoroquinolone-resistant Escherichia coli in community-acquired urinary tract infections.

2. Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.

3. Characterization of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli.

4. Active efflux of chloramphenicol in susceptible Escherichia coli strains and in multiple-antibiotic-resistant (Mar) mutants.

5. Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.

6. Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli.

7. A multidrug resistance regulatory chromosomal locus is widespread among enteric bacteria.

8. Ten-year survey of quinolone resistance in Escherichia coli causing urinary tract infections.

9. Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a non-plasmid-determined efflux of tetracycline.

10. Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences.

Review 1. Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

2. Activation of multiple antibiotic resistance in uropathogenic Escherichia coli strains by aryloxoalcanoic acid compounds.

3. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli.

Review 4. Linkage map of Escherichia coli K-12, edition 10: the traditional map.

Review 5. Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.

6. Defining a rob regulon in Escherichia coli by using transposon mutagenesis.

7. Chromosomal mutations that accompany qnr in clinical isolates of Escherichia coli.

8. Multiple antibiotic resistance in Stenotrophomonas maltophilia.

9. Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae.

Review 10. Dead bugs don't mutate: susceptibility issues in the emergence of bacterial resistance.