Literature DB >> 8722001

Genetic probes of ribosomal RNA function.

M O'Connor1, C A Brunelli, M A Firpo, S T Gregory, K R Lieberman, J S Lodmell, H Moine, D I Van Ryk, A E Dahlberg.   

Abstract

We have used a genetic approach to uncover the functional roles of rRNA in protein synthesis. Mutations were constructed in a cloned rrn operon by site-directed mutagenesis or isolated by genetic selections following random mutagenesis. We have identified mutations that affect each step in the process of translation. The data are consistent with the results of biochemical and phylogenetic analyses but, in addition, have provided novel information on regions of rRNA not previously investigated.

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Year:  1995        PMID： 8722001     DOI： 10.1139/o95-093

Source DB:  PubMed          Journal:  Biochem Cell Biol        ISSN： 0829-8211            Impact factor:   3.626


  20 in total

1.  Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

Authors:  M Pioletti; F Schlünzen; J Harms; R Zarivach; M Glühmann; H Avila; A Bashan; H Bartels; T Auerbach; C Jacobi; T Hartsch; A Yonath; F Franceschi
Journal:  EMBO J       Date:  2001-04-17       Impact factor: 11.598

2.  Suppression of nonsense mutations induced by expression of an RNA complementary to a conserved segment of 23S rRNA.

Authors:  N S Chernyaeva; E J Murgola; A S Mankin
Journal:  J Bacteriol       Date:  1999-09       Impact factor: 3.490

Review 3.  Hydroxylation and translational adaptation to stress: some answers lie beyond the STOP codon.

Authors:  M J Katz; L Gándara; A L De Lella Ezcurra; P Wappner
Journal:  Cell Mol Life Sci       Date:  2016-02-13       Impact factor: 9.261

4.  Multiple defects in translation associated with altered ribosomal protein L4.

Authors:  Michael O'Connor; Steven T Gregory; Albert E Dahlberg
Journal:  Nucleic Acids Res       Date:  2004-10-27       Impact factor: 16.971

5.  Decoding fidelity at the ribosomal A and P sites: influence of mutations in three different regions of the decoding domain in 16S rRNA.

Authors:  M O'Connor; C L Thomas; R A Zimmermann; A E Dahlberg
Journal:  Nucleic Acids Res       Date:  1997-03-15       Impact factor: 16.971

6.  Expansion of the 16S and 23S ribosomal RNA mutation databases (16SMDB and 23SMDB).

Authors:  K L Triman; B J Adams
Journal:  Nucleic Acids Res       Date:  1997-01-01       Impact factor: 16.971

7.  Saturation mutagenesis of 5S rRNA in Saccharomyces cerevisiae.

Authors:  M W Smith; A Meskauskas; P Wang; P V Sergiev; J D Dinman
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

8.  FRET enabled real time detection of RNA-small molecule binding.

Authors:  Yun Xie; Andrew V Dix; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2009-12-09       Impact factor: 15.419

9.  Accuracy modulating mutations of the ribosomal protein S4-S5 interface do not necessarily destabilize the rps4-rps5 protein-protein interaction.

Authors:  Haritha Vallabhaneni; Philip J Farabaugh
Journal:  RNA       Date:  2009-04-22       Impact factor: 4.942

10.  Characterization of functionally active subribosomal particles from Thermus aquaticus.

Authors:  P Khaitovich; A S Mankin; R Green; L Lancaster; H F Noller
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205
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