OBJECTIVE: The purpose of the study was to determine whether psychosocial stress during different life periods could be a risk factor in the etiology/pathogenesis of insulin-dependent diabetes mellitus (IDDM) in children. RESEARCH DESIGN AND METHODS: In a population-based sample of 67 case patients 0-14 years of age and 61 matched healthy control subjects, life events during the entire lifespan before the onset of IDDM were recorded as well as measures of child behavior before onset, social support, and family function. RESULTS: Negative life events occurring during the first 2 years of life, life events with difficult adaptation, child behavioral deviances, and a more chaotic family function were more common in the case group. A stepwise logistic regression indicated that negative life events in the first 2 years increased the risk of IDDM and that premorbid child behavior as well as dysfunctional hierarchical family pattern affect the risk. CONCLUSIONS: Stress early in life may increase the risk for IDDM, presumably by affecting the autoimmune process. To confirm these results, it is necessary to make a truly prospective study.
OBJECTIVE: The purpose of the study was to determine whether psychosocial stress during different life periods could be a risk factor in the etiology/pathogenesis of insulin-dependent diabetes mellitus (IDDM) in children. RESEARCH DESIGN AND METHODS: In a population-based sample of 67 case patients 0-14 years of age and 61 matched healthy control subjects, life events during the entire lifespan before the onset of IDDM were recorded as well as measures of child behavior before onset, social support, and family function. RESULTS: Negative life events occurring during the first 2 years of life, life events with difficult adaptation, child behavioral deviances, and a more chaotic family function were more common in the case group. A stepwise logistic regression indicated that negative life events in the first 2 years increased the risk of IDDM and that premorbid child behavior as well as dysfunctional hierarchical family pattern affect the risk. CONCLUSIONS: Stress early in life may increase the risk for IDDM, presumably by affecting the autoimmune process. To confirm these results, it is necessary to make a truly prospective study.
Authors: Young Sil Eom; Hwa Sun Park; Sei-Hyun Kim; Sun Mee Yang; Moon Suk Nam; Hyoung Woo Lee; Ki Young Lee; Sihoon Lee; Yeun Sun Kim; Ie Byung Park Journal: Diabetes Metab J Date: 2011-04-30 Impact factor: 5.376
Authors: H E Larsson; K Lynch; B Lernmark; A Nilsson; G Hansson; P Almgren; A Lernmark; S-A Ivarsson Journal: Diabetologia Date: 2005-07-01 Impact factor: 10.122
Authors: Tumaini R Coker; Marc N Elliott; Jan L Wallander; Paula Cuccaro; Jo Anne Grunbaum; Rosalie Corona; Ann E Saunders; Mark A Schuster Journal: Arch Pediatr Adolesc Med Date: 2011-04
Authors: K Karavanaki; E Tsoka; M Liacopoulou; C Karayianni; V Petrou; E Pippidou; M Brisimitzi; M Mavrikiou; K Kakleas; C Dacou-Voutetakis Journal: J Endocrinol Invest Date: 2008-05 Impact factor: 4.256
Authors: Haiqun Lin; Kyle A Williams; Liliya Katsovich; Diane B Findley; Heidi Grantz; Paul J Lombroso; Robert A King; Debra E Bessen; Dwight Johnson; Edward L Kaplan; Angeli Landeros-Weisenberger; Heping Zhang; James F Leckman Journal: Biol Psychiatry Date: 2009-10-14 Impact factor: 13.382