| Literature DB >> 872122 |
R A Squire, M B Sporn, C C Brown, J M Smith, M L Wenk, S Springer.
Abstract
An objective system for histopathological and statistical evaluation of rat bladder lesions induced by the carcinogen, N-methyl-N-nitrosourea, is described. This system has been used to measure the inhibitory effects of 13-cis-retinoic acid on the development of bladder cancer in female Wistar/Lewis rats. 13-cis-Retinoic acid caused significant inhibition of development of both preneoplastic and neoplastic lesions in bladder epithelium.Entities:
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Year: 1977 PMID: 872122
Source DB: PubMed Journal: Cancer Res ISSN: 0008-5472 Impact factor: 12.701