Literature DB >> 8720955

[Congenital bile duct cysts and liver fibrosis in a foal].

H Stocker1, B Kaser-Hotz, C Lischer, I Zahn, F Ehrensperger.   

Abstract

A three-week-old foal was submitted to the clinic because of a minor traumatic injury at the lower jaw. At admission the foal exhibited diarrhea, a distended abdomen and reduced general condition. These findings could not be associated with the injury. On abdominal radiography decreased abdominal detail and a dorsocaudal displacement of the intestine was present. Ultrasonographically multiple fluid-filled cystic structures of several centimeters in diameter were identified. These cystic structures appeared to be associated with the liver. At laparotomy and at necropsy the liver was markedly enlarged and firm and had large, thin-walled, with a bile-like fluid filled cysts, 4-20 centimeters in diameter. Histological lesions were characterized by proliferation of small bile ducts and of interlobular connective tissue as well as focal subacute cholangitis. Gross and histological findings were considered to be consistent with congenital polycystic liver disease and fibrosis with ascending cholangitis.

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Mesh:

Year:  1996        PMID: 8720955

Source DB:  PubMed          Journal:  Tierarztl Prax        ISSN: 0303-6286


  1 in total

1.  Congenital hepatic fibrosis in the Franches-Montagnes horse is associated with the polycystic kidney and hepatic disease 1 (PKHD1) gene.

Authors:  Michaela Drögemüller; Vidhya Jagannathan; Monika M Welle; Claudia Graubner; Reto Straub; Vinzenz Gerber; Dominik Burger; Heidi Signer-Hasler; Pierre-André Poncet; Stéphane Klopfenstein; Ruedi von Niederhäusern; Jens Tetens; Georg Thaller; Stefan Rieder; Cord Drögemüller; Tosso Leeb
Journal:  PLoS One       Date:  2014-10-08       Impact factor: 3.240

  1 in total

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