Dyshormia revisited: generalized seizures and arousal.

Niedermeyer has described dyshormia, or deviant arousal, and related this EEG pattern to generalized seizures. We describe a patient with generalized seizures who in the same EEG had spindles transforming into generalized epileptiform discharges and generalized epileptiform discharges transforming into spindles. This suggests that similar neural circuitry may underlie both spindles and generalized epileptiform discharges, and that the mechanism described by Gloor for feline generalized penicillin induced epilepsy may also apply to some humans with generalized epilepsies.