| Literature DB >> 8717036 |
P Bhanot1, M Brink, C H Samos, J C Hsieh, Y Wang, J P Macke, D Andrew, J Nathans, R Nusse.
Abstract
Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.Entities:
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Year: 1996 PMID： 8717036 DOI： 10.1038/382225a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962