Literature DB >> 8712153

Effects of in vivo cocaine administration on human platelet aggregation.

C M Heesch1, B H Negus, M Steiner, I I Snyder RW, D D McIntire, P A Grayburn, J Ashcraft, J A Hernández, E J Eichhorn.   

Abstract

To evaluate whether cocaine administration to human volunteers in vivo increases platelet aggregation, 12 healthy male volunteers were studied twice in a prospective, double-blinded fashion. There was a decrease in aggregation following cocaine exposure compared to placebo, which was most prominent at high doses of adenosine diphosphate.

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Year:  1996        PMID: 8712153     DOI: 10.1016/s0002-9149(96)90406-3

Source DB:  PubMed          Journal:  Am J Cardiol        ISSN: 0002-9149            Impact factor:   2.778


  3 in total

1.  Cocaine activates platelets and increases the formation of circulating platelet containing microaggregates in humans.

Authors:  C M Heesch; C R Wilhelm; J Ristich; J Adnane; F A Bontempo; W R Wagner
Journal:  Heart       Date:  2000-06       Impact factor: 5.994

2.  Cocaine Use and Splenic Rupture: A Rare Yet Serious Association.

Authors:  Nishrutha Karthik; Karthik Gnanapandithan
Journal:  Clin Pract       Date:  2016-08-11

3.  Cocaine and thrombosis: a narrative systematic review of clinical and in-vivo studies.

Authors:  Nat Mj Wright; Matthew Martin; Tom Goff; John Morgan; Rebecca Elworthy; Shariffe Ghoneim
Journal:  Subst Abuse Treat Prev Policy       Date:  2007-09-19
  3 in total

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