Literature DB >> 8710192

Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil.

T Tokime1, K Nozaki, H Kikuchi.   

Abstract

Delayed neuronal death (DND) in CA1 region after transient global ischemia is a well-known phenomenon, but its mechanism has not been clarified. In order to examine the involvement of nitric oxide (NO) in DND, 7-nitro indazole (7NI), a selective neuronal NO synthase (nNOS) inhibitor, and FK506, an immunosuppressant which also inhibits nNOS, were administered intraperitoneally during and after transient global ischemia in gerbil. FK506 moderately ameliorated DND in a dose-dependent manner. However, 7NI showed only minor neuroprotective effects. These results show that DND is not mainly mediated by NO production via nNOS, and FK506 acts as a neuroprotective agent via unknown pathways other than nNOS inhibition.

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Year:  1996        PMID： 8710192     DOI： 10.1016/s0304-3940(96)12438-1

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  8 in total

1.  Post-ischemic alterations in [3H]FK506 binding in the gerbil and rat brains.

Authors:  T Araki; H Kato; K Shuto; Y Itoyama
Journal:  Metab Brain Dis       Date:  1998-03       Impact factor: 3.584

2.  Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia.

Authors:  K J Becker; R M McCarron; C Ruetzler; O Laban; E Sternberg; K C Flanders; J M Hallenbeck
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

3.  Increases in [3H]FK-506 and [3H]L-N(G)-nitro-arginine binding in the rat brain after nigrostriatal dopaminergic denervation.

Authors:  T Araki; H Tanji; K Fujihara; H Kato; Y Itoyama
Journal:  Metab Brain Dis       Date:  1999-03       Impact factor: 3.584

Review 4.  FK506 and the role of immunophilins in nerve regeneration.

Authors:  B G Gold
Journal:  Mol Neurobiol       Date:  1997-12       Impact factor: 5.590

5.  Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus.

Authors:  T Sugino; K Nozaki; Y Takagi; I Hattori; N Hashimoto; T Moriguchi; E Nishida
Journal:  J Neurosci       Date:  2000-06-15       Impact factor: 6.167

6.  Effects of long-term FK506 administration on functional and histopathological outcome after spinal cord injury in adult rat.

Authors:  Kamila Saganová; Judita Orendácová; Igor Sulla; Peter Filipcík; Dása Cízková; Ivo Vanický
Journal:  Cell Mol Neurobiol       Date:  2009-04-07       Impact factor: 5.046

Review 7.  Potential of immunosuppressive agents in cerebral ischaemia.

Authors:  Yogendra Kumar Gupta; Anjali Chauhan
Journal:  Indian J Med Res       Date:  2011-01       Impact factor: 2.375

8.  Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat.

Authors:  Zahra-Nadia Sharifi; Farid Abolhassani; Mohammad Reza Zarrindast; Shabnam Movassaghi; Nasrin Rahimian; Gholamreza Hassanzadeh
Journal:  Stroke Res Treat       Date:  2011-09-15
  8 in total

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