| Literature DB >> 8709100 |
H Park1, M Hepperle, T C Boge, R H Himes, G I Georg.
Abstract
The synthesis and biological evaluation of the two known phenolic metabolites of paclitaxel are described. The C3'-phenolic metabolite 2 of paclitaxel was prepared from 7-(triethylsilyl)-baccatin III (8) and enantioenriched N-benzoyl-2-azetidinone 7. The C2-phenolic metabolite 3 was synthesized from paclitaxel (1a) via selective C2 debenzoylation and reacylation.Entities:
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Year: 1996 PMID： 8709100 DOI： 10.1021/jm960142x
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446