Literature DB >> 870885

The action of piracetam on 14C-glucose metabolism in normal and posthypoxic rat cerebral cortex slices.

K Domańska-Janik, M Zaleska.   

Abstract

The stimulating effect of piracetam on the respiration and glycolysis was observed in rat brain cortex slices incubated under oxygen atmosphere. After preincubation of the slices under pure nitrogen atmosphere, piracetam infuenced also decarboxylation of the C1-glucose carbon, indicating stimulation of the pentose cysle. Any significant effect of piracetam on the lowered by anoxia incorporation of 14C from U-14C-glucose into macromolecular fractions was not observed. The results have supported a protective effect of piracetam against oxygen deficiency, caused mainly by stimulation of metabolic glucose pathways, connected with energy production in CNS.

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Year:  1977        PMID： 870885

Source DB:  PubMed          Journal:  Pol J Pharmacol Pharm        ISSN： 0301-0244


  7 in total

1.  The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by beta-amyloid peptide.

Authors:  C Kurz; I Ungerer; U Lipka; S Kirr; T Schütt; A Eckert; K Leuner; W E Müller
Journal:  Br J Pharmacol       Date:  2010-03-09       Impact factor: 8.739

2.  Effects of centrophenoxine, piracetam and hydergine on rat brain lipid peroxidation.

Authors:  D D Jamieson; K M Taylor
Journal:  Experientia       Date:  1981

3.  Piracetam improves mitochondrial dysfunction following oxidative stress.

Authors:  Uta Keil; Isabel Scherping; Susanne Hauptmann; Katin Schuessel; Anne Eckert; Walter E Müller
Journal:  Br J Pharmacol       Date:  2006-01       Impact factor: 8.739

Review 4.  Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.

Authors:  Gunter P Eckert; Kathrin Renner; Schamim H Eckert; Janett Eckmann; Stephanie Hagl; Reham M Abdel-Kader; Christopher Kurz; Kristina Leuner; Walter E Muller
Journal:  Mol Neurobiol       Date:  2012-05-03       Impact factor: 5.590

Review 5.  Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects.

Authors:  Walter E Müller; Anne Eckert; Christopher Kurz; Gunter Peter Eckert; Kristina Leuner
Journal:  Mol Neurobiol       Date:  2010-05-12       Impact factor: 5.590

6.  Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam.

Authors:  Kristina Leuner; Christopher Kurz; Giorgio Guidetti; Jean-Marc Orgogozo; Walter E Müller
Journal:  Front Neurosci       Date:  2010-09-07       Impact factor: 4.677

Review 7.  Piracetam. An overview of its pharmacological properties and a review of its therapeutic use in senile cognitive disorders.

Authors:  M W Vernon; E M Sorkin
Journal:  Drugs Aging       Date:  1991-01       Impact factor: 3.923
  7 in total

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