Literature DB >> 8707745

Production of metal dependent beta-lactamases by clinical strains of Bacteroides fragilis isolated before 1987.

T Khushi1, D J Payne, A Fosberry, C Reading.   

Abstract

Five imipenem resistant clinical isolates of Bacteroides fragilis isolated before 1987, were examined to determine if they produced metallo-beta-lactamases. The beta-lactamases produced by the clinical isolates all focused as doublet bands at pl 4.8/4.9, characteristic of the B. fragilis CfiA type metallo-beta-lactamase. Each enzyme had a similar substrate profile and were inhibited by EDTA and activated with zinc sulphate. The sequence of the metallo-beta-lactamase gene from B. fragilis ED262 was determined and confirmed to be a CfiA type beta-lactamase. Consequently, the five isolates examined probably produce a CfiA type beta-lactamase, suggesting that metallo-beta-lactamases were present before the widespread use of carbapenems.

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Year:  1996        PMID： 8707745     DOI： 10.1093/jac/37.2.345

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  5 in total

1.  Isolation of multidrug-resistant Stenotrophomonas maltophilia from cultured yellowtail (Seriola quinqueradiata) from a marine fish farm.

Authors:  Manabu Furushita; Akira Okamoto; Toshimichi Maeda; Michio Ohta; Tsuneo Shiba
Journal:  Appl Environ Microbiol       Date:  2005-09       Impact factor: 4.792

Review 2.  Carbapenem-hydrolyzing beta-lactamases.

Authors:  B A Rasmussen; K Bush
Journal:  Antimicrob Agents Chemother       Date:  1997-02       Impact factor: 5.191

3.  Distribution of the cfiA gene among Bacteroides fragilis strains in Japan and relatedness of cfiA to imipenem resistance.

Authors:  K Yamazoe; N Kato; H Kato; K Tanaka; Y Katagiri; K Watanabe
Journal:  Antimicrob Agents Chemother       Date:  1999-11       Impact factor: 5.191

4.  Inhibition of metallo-beta-lactamases by a series of mercaptoacetic acid thiol ester derivatives.

Authors:  D J Payne; J H Bateson; B C Gasson; D Proctor; T Khushi; T H Farmer; D A Tolson; D Bell; P W Skett; A C Marshall; R Reid; L Ghosez; Y Combret; J Marchand-Brynaert
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

5.  Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases.

Authors:  David J Payne; Juan Antonio Hueso-Rodríguez; Helen Boyd; Néstor O Concha; Cheryl A Janson; Martin Gilpin; John H Bateson; Christy Cheever; Nancy L Niconovich; Stewart Pearson; Stephen Rittenhouse; David Tew; Emilio Díez; Paloma Pérez; Jesus De La Fuente; Michael Rees; Alfonso Rivera-Sagredo
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191
  5 in total

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