Literature DB >> 8706835

Characterization of a new peptide from Tityus serrulatus scorpion venom which is a ligand of the apamin-binding site.

C Legros1, R Oughuideni, H Darbon, H Rochat, P E Bougis, M F Martin-Eauclaire.   

Abstract

A new ligand (Ts kappa) of the apamin binding site on rat brain synaptosomes (K0.5 = 300 pM) was purified and characterized from the venom of Tityus serrulatus. It is a polypeptide toxin of 35 amino acid residues, with three disulfide bridges. Its cDNA was amplified from a venom gland cDNA library and the nucleotide sequence determined. A model of Ts kappa was constructed by amino acid replacement using charybdotoxin structure as determined by 1H nuclear magnetic resonance as starting model.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8706835     DOI： 10.1016/0014-5793(96)00616-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Genomic organization of three novel toxins from the scorpion Buthus martensi Karsch that are active on potassium channels.

Authors:  L Dai; J J Wu; Y H Gu; Z D Lan; M H Ling; C W Chi
Journal:  Biochem J       Date:  2000-03-15       Impact factor: 3.857

2.  Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: solution structure of the potassium channel inhibitor HsTX1.

Authors:  P Savarin; R Romi-Lebrun; S Zinn-Justin; B Lebrun; T Nakajima; B Gilquin; A Menez
Journal:  Protein Sci       Date:  1999-12       Impact factor: 6.725

3.  Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices.

Authors:  Jacqueline Scuvée-Moreau; Andre Boland; Amaury Graulich; Lionel Van Overmeire; Dieter D'hoedt; Fabienne Graulich-Lorge; Elizabeth Thomas; Aude Abras; Martin Stocker; Jean-Francois Liégeois; Vincent Seutin
Journal:  Br J Pharmacol       Date:  2004-10-25       Impact factor: 8.739

Review 4.  Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.

Authors:  P Pedarzani; M Stocker
Journal:  Cell Mol Life Sci       Date:  2008-10       Impact factor: 9.261

5.  Tityustoxin-K(alpha) blockade of the voltage-gated potassium channel Kv1.3.

Authors:  Aldo Rogelis A Rodrigues; Eliane C Arantes; Francisco Monje; Walter Stühmer; Wamberto Antonio Varanda
Journal:  Br J Pharmacol       Date:  2003-07       Impact factor: 8.739
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.