| Literature DB >> 8706791 |
Abstract
A human T cell culture system has been developed to study cellular senescence in a manner analogous to that used for fibroblasts. Using this system, several markers of replicative senescence have been identified. Evidence is provided to show that new insights into the immune deficiency of aging as well as HIV infection have emerged from the in vitro model. The culture model is now being exploited to dissect the basic mechanisms underlying the senescence program in T cells.Entities:
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Year: 1996 PMID： 8706791 DOI： 10.1016/0531-5565(95)00017-8
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032