| Literature DB >> 870655 |
S McIntosh, D L Davidson, R T O'Brien, H A Pearson.
Abstract
Percutaneous liver biopsy was performed on seven children with acute lymphocytic leukemia who had received maintanance chemotherapy with high-dose intravenous methotrexate for 1 1/2 to 2 1/2 years. Portal fibrosis was found in four of the seven children and in an additional patient treated with oral methotrexate. Serial tests of liver function and 99mtechnetium-sulfur-colloid scans did not accurately identify children with hepatic fibrosis. Clinical evidence of liver disease was not seen.Entities:
Mesh：
Substances：
Year: 1977 PMID： 870655 DOI： 10.1016/s0022-3476(77)80587-8
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406