Literature DB >> 8706177

[Study on antifertility mechanisms of tripchlorolide (T4)].

X Zuo1, N Wang.   

Abstract

Hyaluronidase activities of testes and epididymides in rats were obviously inhibited by T4 po at dosage of 0.1 mg.kg-1/d for 7 weeks. T4 at dosage of 0.1 mg.kg-1/d for 3 weeks decreased GSH content in epididymides in rats. However, in vitro T4 at concentration of 10 micrograms/ml was found to exert no effect on the content of malondialdehyde in testis or H2O2 in testis and epididymis microsomes in rats.

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Year:  1995        PMID: 8706177

Source DB:  PubMed          Journal:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao        ISSN: 1000-503X


  1 in total

1.  Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates.

Authors:  Zongliang Chang; Weibing Qin; Huili Zheng; Kathleen Schegg; Lu Han; Xiaohua Liu; Yue Wang; Zhuqing Wang; Hayden McSwiggin; Hongying Peng; Shuiqiao Yuan; Jiabao Wu; Yongxia Wang; Shenghui Zhu; Yanjia Jiang; Hua Nie; Yuan Tang; Yu Zhou; Michael J M Hitchcock; Yunge Tang; Wei Yan
Journal:  Nat Commun       Date:  2021-02-23       Impact factor: 14.919

  1 in total

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