Literature DB >> 8706034

Preliminary report: the short-term effects of direct p53 DNA injection in primary hepatocellular carcinomas.

N A Habib1, S F Ding, R el-Masry, R R Mitry, K Honda, N E Michail, G Dalla Serra, G Izzi, L Greco, M Bassyouni, M el-Toukhy, Y Abdel-Gaffar.   

Abstract

A pilot study, to assess the therapeutic potential of percutaneous injection of wild-type p53 (wt-p53) in five patients with primary hepatocellular carcinoma is reported. Three of the five patients showed objective tumor response with reduction of the tumor volume on computed tomographic (CT) scan measurements as well as a significant fall of serum alphafetoprotein. Much further work will be needed to elucidate the mechanism of action.

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Year:  1996        PMID： 8706034

Source DB:  PubMed          Journal:  Cancer Detect Prev        ISSN： 0361-090X


  8 in total

Review 1.  Therapeutic genes for cancer gene therapy.

Authors:  W Walther; U Stein
Journal:  Mol Biotechnol       Date:  1999-11       Impact factor: 2.695

2.  Advances in Gene Delivery Systems.

Authors:  Kenya Kamimura; Takeshi Suda; Guisheng Zhang; Dexi Liu
Journal:  Pharmaceut Med       Date:  2011-10-01

Review 3.  Physical approaches for nucleic acid delivery to liver.

Authors:  Kenya Kamimura; Dexi Liu
Journal:  AAPS J       Date:  2008-12-13       Impact factor: 4.009

4.  Anti-liver cancer activity of TNF-related apoptosis-inducing ligand gene and its bystander effects.

Authors:  Chao He; Wei-Feng Lao; Xiao-Tong Hu; Xiang-Ming Xu; Jing Xu; Bing-Liang Fang
Journal:  World J Gastroenterol       Date:  2004-03-01       Impact factor: 5.742

Review 5.  Cellular and molecular targets for the immunotherapy of hepatocellular carcinoma.

Authors:  Vikrant Rai; Joe Abdo; Abdullah N Alsuwaidan; Swati Agrawal; Poonam Sharma; Devendra K Agrawal
Journal:  Mol Cell Biochem       Date:  2017-06-07       Impact factor: 3.842

6.  Establishment of a doxycycline-regulated cell line with inducible, doubly-stable expression of the wild-type p53 gene from p53-deleted hepatocellular carcinoma cells.

Authors:  Tian-Yi Chi; George G Chen; Lok-Kee Ho; Paul B S Lai
Journal:  Cancer Cell Int       Date:  2005-08-23       Impact factor: 5.722

7.  p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation.

Authors:  K Honda; E Sbisà; A Tullo; P A Papeo; C Saccone; S Poole; M Pignatelli; R R Mitry; S Ding; A Isla; A Davies; N A Habib
Journal:  Br J Cancer       Date:  1998-03       Impact factor: 7.640

8.  Suicide gene therapy in liver tumors.

Authors:  Long R Jiao; Roman Havlik; Joanna Nicholls; Steen Lindkaer Jensen; Nagy A Habib
Journal:  Methods Mol Med       Date:  2004
  8 in total

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