Literature DB >> 8706012

A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression.

M Suganuma1, S Okabe, E Sueoka, N Iida, A Komori, S J Kim, H Fujiki.   

Abstract

Mechanisms of cancer prevention were studied using structurally different cancer-preventive agents, sarcophytol A, canventol, (-)-epigallo-catechin gallate, and tamoxifen, based on our evidence that tumor necrosis factor alpha (TNF-alpha) acts as an endogenous tumor promoter relevant to human carcinogenesis. Pretreatment with the four preventive agents commonly inhibited TNF-alpha mRNA expression and TNF-alpha release in BALB/3T3 cells induced by a tumor promoter, okadaic acid, whereas the expression of early response genes (c-jun, junB, c-fos, and fosB) was enhanced. These results strongly suggest that inhibition of TNF-alpha mRNA expression and its release is a new process of cancer prevention.

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Year:  1996        PMID： 8706012

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  14 in total

Review 1.  Suppression of tumour development by substances derived from the diet--mechanisms and clinical implications.

Authors:  A Gescher; U Pastorino; S M Plummer; M M Manson
Journal:  Br J Clin Pharmacol       Date:  1998-01       Impact factor: 4.335

2.  Expression of the tumor necrosis factor alpha gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes.

Authors:  E Sueoka; N Sueoka; S Okabe; T Kozu; A Komori; T Ohta; M Suganuma; S J Kim; I K Lim; H Fujiki
Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

3.  In vitro and in vivo activities of tea catechins against Helicobacter pylori.

Authors:  K Mabe; M Yamada; I Oguni; T Takahashi
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

4.  The promoting effect of tumour necrosis factor alpha in radiation-induced cell transformation.

Authors:  R F Guo; Y F Gong
Journal:  Br J Cancer       Date:  1998-04       Impact factor: 7.640

5.  New lobane and cembrane diterpenes from two comorian soft corals.

Authors:  Isabelle Bonnard; Sabina B Jhaumeer-Laulloo; Nataly Bontemps; Bernard Banaigs; Maurice Aknin
Journal:  Mar Drugs       Date:  2010-02-23       Impact factor: 5.118

6.  Carcinogenic potential of tobacco tar-resistant Staphylococcus aureus in buccal cavity.

Authors:  H Fujiki; H Takeuchi; N Nishitani; H Yamanaka; K Suzuki; M Kurusu; M Suganuma
Journal:  J Cancer Res Clin Oncol       Date:  2004-03-11       Impact factor: 4.553

7.  Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice.

Authors:  Rosanna Di Paola; Emanuela Mazzon; Carmelo Muià; Tiziana Genovese; Marta Menegazzi; Raffaela Zaffini; Hisanory Suzuki; Salvatore Cuzzocrea
Journal:  Respir Res       Date:  2005-06-29

8.  Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients.

Authors:  H C Li; S Yashiki; J Sonoda; H Lou; S K Ghosh; J J Byrnes; C Lema; T Fujiyoshi; M Karasuyama; S Sonoda
Journal:  Jpn J Cancer Res       Date:  2000-01

9.  Disaccharide esters screened for inhibition of tumor necrosis factor-alpha release are new anti-cancer agents.

Authors:  S Okabe; M Suganuma; Y Tada; Y Ochiai; E Sueoka; H Kohya; A Shibata; M Takahashi; M Mizutani; T Matsuzaki; H Fujiki
Journal:  Jpn J Cancer Res       Date:  1999-06

10.  Dose-response on the chemopreventive effects of sarcophine-diol on UVB-induced skin tumor development in SKH-1 hairless mice.

Authors:  Ruth F Guillermo; Xiaoying Zhang; Radhey S Kaushik; David Zeman; Safwat A Ahmed; Sherief Khalifa; Hesham Fahmy; Chandradhar Dwivedi
Journal:  Mar Drugs       Date:  2012-09-24       Impact factor: 6.085
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