Literature DB >> 8705299

Regionally specific induction of ICE mRNA and enzyme activity in the rat brain and adrenal gland by LPS.

S Tingsborg1, M Zetterström, K Alheim, H Hasanvan, M Schultzberg, T Bartfai.   

Abstract

Pro interleukin-1 beta converting enzyme (ICE) activity in the pituitary was found to be significantly increased 4 h after intraperitoneal injection of E. coli lipopolysaccharides, when distribution and inducibility of the enzyme was studied in the adult rat brain and the adrenal gland, using an artificial fluorescence peptide substrate. The same lipopolysaccharide treatment induced ICE mRNA levels in the pituitary, adrenal gland and hypothalamus as studied by reverse transcript-polymerase chain reaction.

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Year:  1996        PMID: 8705299     DOI: 10.1016/0006-8993(95)01525-6

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


  2 in total

1.  Hyperresponsive febrile reactions to interleukin (IL) 1alpha and IL-1beta, and altered brain cytokine mRNA and serum cytokine levels, in IL-1beta-deficient mice.

Authors:  K Alheim; Z Chai; G Fantuzzi; H Hasanvan; D Malinowsky; E Di Santo; P Ghezzi; C A Dinarello; T Bartfai
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

2.  Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation.

Authors:  Minho Lee; Na Young Lee; Kyung-Sook Chung; Se-Yun Cheon; Kyung-Tae Lee; Hyo-Jin An
Journal:  Sci Rep       Date:  2017-01-31       Impact factor: 4.379

  2 in total

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