Literature DB >> 8704740

A role for the mineralocorticoid receptor in a rapid and transient suppression of hippocampal 5-HT1A receptor mRNA by corticosterone.

O C Meijer1, E R de Kloet.   

Abstract

The interaction between corticosterone and hippocampal 5-HT1A receptor mRNA expression was investigated in male rats. Two days after adrenalectomy, 5-HT1A receptor mRNA was increased in the granule cell layer of the dentate gyrus. Injection of corticosterone led to a significant dose-dependent and transient suppression of 5-HT1A receptor mRNA. The effect of a low dose of corticosterone (50 micrograms/kg) could be blocked by RU 28318, a specific mineralocorticoid receptor antagonist, but not by RU 38486, a glucocorticoid antagonist. The effect of a higher dose of corticosterone (300 micrograms/kg) could be partially blocked by RU 28318, whereas there was no additional effect of RU 38486. These results point to a stringent regulation of hippocampal 5-HT1A receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor.

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Year:  1995        PMID： 8704740     DOI： 10.1111/j.1365-2826.1995.tb00804.x

Source DB:  PubMed          Journal:  J Neuroendocrinol        ISSN： 0953-8194            Impact factor:   3.627


  16 in total

1.  Corticosteroids regulate 5-HT(1A) but not 5-HT(1B) receptor mRNA in rat hippocampus.

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Journal:  Brain Res Mol Brain Res       Date:  2000-10-20

2.  Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression.

Authors:  Allison C Nugent; Earle E Bain; Paul J Carlson; Alexander Neumeister; Omer Bonne; Richard E Carson; William Eckelman; Peter Herscovitch; Carlos A Zarate; Dennis S Charney; Wayne C Drevets
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Review 3.  Molecular dissection of corticosteroid action in the rat hippocampus. Application of the differential display techniques.

Authors:  E Vreugdenhil; J de Jong; M J Schaaf; O C Meijer; J Busscher; C Vuijst; E R de Kloet
Journal:  J Mol Neurosci       Date:  1996       Impact factor: 3.444

Review 4.  Transcriptional regulation of the 5-HT1A receptor: implications for mental illness.

Authors:  Paul R Albert
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-09-05       Impact factor: 6.237

Review 5.  Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter.

Authors:  Alexander Neumeister; Theresa Young; Juergen Stastny
Journal:  Psychopharmacology (Berl)       Date:  2004-07-13       Impact factor: 4.530

6.  Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.

Authors:  Julie G Hensler; Miriam A Vogt; Peter Gass
Journal:  Psychoneuroendocrinology       Date:  2009-09-18       Impact factor: 4.905

Review 7.  Serotonin-1A receptor imaging in recurrent depression: replication and literature review.

Authors:  Wayne C Drevets; Michael E Thase; Eydie L Moses-Kolko; Julie Price; Ellen Frank; David J Kupfer; Chester Mathis
Journal:  Nucl Med Biol       Date:  2007-10       Impact factor: 2.408

8.  Crossroads of corticotropin releasing hormone, corticosteroids and monoamines. About a biological interface between stress and depression.

Authors:  H. M. Van Praag
Journal:  Neurotox Res       Date:  2002 Aug-Sep       Impact factor: 3.911

9.  Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability.

Authors:  Qiang Wei; Xin-Yun Lu; Li Liu; Gwen Schafer; Kun-Ruey Shieh; Sharon Burke; Terry E Robinson; Stanley J Watson; Audrey F Seasholtz; Huda Akil
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-27       Impact factor: 11.205

10.  Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression.

Authors:  Allison C Nugent; Paul J Carlson; Earle E Bain; William Eckelman; Peter Herscovitch; Husseini Manji; Carlos A Zarate; Wayne C Drevets
Journal:  J Psychopharmacol       Date:  2013-08-07       Impact factor: 4.153
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