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Literature DB >> 8704186

Kaposi's sarcoma (KS)-associated herpesvirus-like DNA sequences in peripheral blood mononuclear cells: association with KS and persistence in patients receiving anti-herpesvirus drugs.

R W Humphrey¹, T R O'Brien, F M Newcomb, H Nishihara, K M Wyvill, G A Ramos, M W Saville, J J Goedert, S E Straus, R Yarchoan.

Abstract

Herpesvirus-like DNA sequences (KSHV/HHV-8) have recently been described in AIDS-associated Kaposi's sarcoma (KS) lesions. Many questions remain regarding the role of this virus in KS and the therapeutic implications of this finding. In the current study, KSHV/HHV-8 DNA was detected in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus (HIV)-infected patients with KS (34/98) more often than in HIV-infected individuals without KS (12/64, P = .03). The detection of KSHV/HHV-8 DNA did not correlate with the CD4 lymphocyte count. Five patients demonstrated KSHV/HHV-8 DNA in their PBMCs during administration of intravenous foscarnet and/or ganciclovir. The continued detection of KSHV/HHV-8 DNA in the PBMCs of patients receiving these anti-herpesvirus drugs has potential implications regarding the virus-cell relationship of KSHV/HHV-8, as well as for the value of these drugs in treating or preventing KS, but additional studies are needed.

Entities: Chemical Disease Species

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Year: 1996 PMID： 8704186

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

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Cited

16 in total

1. Identification and rapid quantification of early- and late-lytic human herpesvirus 8 infection in single cells by flow cytometric analysis: characterization of antiherpesvirus agents.

Authors: J P Zoeteweij; S T Eyes; J M Orenstein; T Kawamura; L Wu; B Chandran; B Forghani; A Blauvelt
Journal: J Virol Date: 1999-07 Impact factor: 5.103

2. Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.

Authors: E A Gustafson; R F Schinazi; J D Fingeroth
Journal: J Virol Date: 2000-01 Impact factor: 5.103

3. Contradictory Concepts in the Etiology and Regression of Kaposi's Sarcoma. The Ferenc Györkey Memorial Lecture.

Authors: Joseph G Sinkovics
Journal: Pathol Oncol Res Date: 1996 Impact factor: 3.201

4. Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV.

Authors: Zhiqiang Qin; Michael DeFee; Jennifer S Isaacs; Chris Parsons
Journal: Virology Date: 2010-05-06 Impact factor: 3.616

10. Human herpesvirus 8 DNA load in leukocytes of human immunodeficiency virus-infected subjects: correlation with the presence of Kaposi's sarcoma and response to anticytomegalovirus therapy.

Authors: G Boivin; A Gaudreau; E Toma; R Lalonde; J P Routy; G Murray; J Handfield; M G Bergeron
Journal: Antimicrob Agents Chemother Date: 1999-02 Impact factor: 5.191

Kaposi's sarcoma (KS)-associated herpesvirus-like DNA sequences in peripheral blood mononuclear cells: association with KS and persistence in patients receiving anti-herpesvirus drugs.

1. Identification and rapid quantification of early- and late-lytic human herpesvirus 8 infection in single cells by flow cytometric analysis: characterization of antiherpesvirus agents.

2. Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.

3. Contradictory Concepts in the Etiology and Regression of Kaposi's Sarcoma. The Ferenc Györkey Memorial Lecture.

4. Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV.

5. Comparison of serologic assays and PCR for diagnosis of human herpesvirus 8 infection.

6. Human Herpesvirus 8 Infections.

Review 7. A risk and benefit assessment of treatment for AIDS-related Kaposi's sarcoma.

Review 8. Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseases.

9. Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood.

10. Human herpesvirus 8 DNA load in leukocytes of human immunodeficiency virus-infected subjects: correlation with the presence of Kaposi's sarcoma and response to anticytomegalovirus therapy.