Literature DB >> 8703994

Structure and expression of the promoter for the R4/ALK5 human type I transforming growth factor-beta receptor: regulation by TGF-beta.

B B Bloom1, D E Humphries, P P Kuang, A Fine, R H Goldstein.   

Abstract

The type I transforming growth factor-beta (TGF-beta) receptors are serine/threonine kinases that are essential for the action of TGF-beta. In this paper, we describe the molecular cloning and expression of the R4/ALK5 human type I TGF-beta receptor promoter. DNA sequence analysis indicates that the promoter lacks a TATA and CAAT box but is highly GC-rich and contains putative Sp1 binding sites. The transcriptional start site is approx. 232 base pairs upstream of the AUG start codon. In human lung fibroblasts, TGF-beta induced a 3-fold increase in steady-state level for type I receptor mRNA. Exposure of cells transfected with a 618 bp promoter fragment to TGF-beta 1 up-regulated transcriptional activity indicating that a TGF-beta response element is contained within this region.

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Year:  1996        PMID： 8703994     DOI： 10.1016/0167-4889(96)00043-2

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  11 in total

1.  Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar.

Authors:  P Schmid; P Itin; G Cherry; C Bi; D A Cox
Journal:  Am J Pathol       Date:  1998-02       Impact factor: 4.307

2.  Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta.

Authors:  X H Feng; X Lin; R Derynck
Journal:  EMBO J       Date:  2000-10-02       Impact factor: 11.598

3.  Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling.

Authors:  Taihao Quan; Tianyuan He; Sewon Kang; John J Voorhees; Gary J Fisher
Journal:  Am J Pathol       Date:  2004-09       Impact factor: 4.307

4.  Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1.

Authors:  Eva M Garrido-Martin; Francisco J Blanco; Africa Fernandez-L; Carmen Langa; Calvin P Vary; Ursula E Lee; Scott L Friedman; Luisa M Botella; Carmelo Bernabeu
Journal:  BMC Mol Biol       Date:  2010-06-29       Impact factor: 2.946

5.  Mechanisms of decreased expression of transforming growth factor-beta receptor type I at late stages of HPV16-mediated transformation.

Authors:  Melissa K Hypes; Lucia Pirisi; Kim E Creek
Journal:  Cancer Lett       Date:  2009-04-02       Impact factor: 8.679

6.  Ionizing radiation induces a motile phenotype in human carcinoma cells in vitro through hyperactivation of the TGF-beta signaling pathway.

Authors:  Cedric Carl; Anne Flindt; Julian Hartmann; Markus Dahlke; Dirk Rades; Jürgen Dunst; Hendrik Lehnert; Frank Gieseler; Hendrik Ungefroren
Journal:  Cell Mol Life Sci       Date:  2015-08-04       Impact factor: 9.261

7.  Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2.

Authors:  Nikolaus Schultz; Dina R Marenstein; Dino A De Angelis; Wei-Qing Wang; Sven Nelander; Anders Jacobsen; Debora S Marks; Joan Massagué; Chris Sander
Journal:  Silence       Date:  2011-03-14

8.  Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta.

Authors:  Catherine Baugé; Olivier Cauvard; Sylvain Leclercq; Philippe Galéra; Karim Boumédiene
Journal:  Arthritis Res Ther       Date:  2011-02-15       Impact factor: 5.156

9.  Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.

Authors:  Laurie M G de Kroon; Roberto Narcisi; Esmeralda N Blaney Davidson; Mairéad A Cleary; Henk M van Beuningen; Wendy J L M Koevoet; Gerjo J V M van Osch; Peter M van der Kraan
Journal:  PLoS One       Date:  2015-12-31       Impact factor: 3.240

10.  Localization of TGF-beta type II receptor and ED-A fibronectin in normal conjunctiva and failed filtering blebs.

Authors:  Tobias Meyer-Ter-Vehn; Franz Grehn; Günther Schlunck
Journal:  Mol Vis       Date:  2008-01-25       Impact factor: 2.367
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