Literature DB >> 8703054

Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).

S L Lee1, Y Sadovsky, A H Swirnoff, J A Polish, P Goda, G Gavrilina, J Milbrandt.   

Abstract

The immediate-early transcription factor NGFI-A (also called Egr-1, zif/268, or Krox-24) is thought to couple extracellular signals to changes in gene expression. Although activins and inhibins regulate follicle-stimulating hormone (FSH) synthesis, no factor has been identified that exclusively regulates luteinizing hormone (LH) synthesis. An analysis of NGFI-A-deficient mice derived from embryonic stem cells demonstrated female infertility that was secondary to LH-beta deficiency. Ovariectomy led to increased amounts of FSH-beta but not LH-beta messenger RNA, which suggested a pituitary defect. A conserved, canonical NGFI-A site in the LH-beta promoter was required for synergistic activation by NGFI-A and steroidogenic factor-1 (SF-1). NGFI-A apparently influences female reproductive capacity through its regulation of LH-beta transcription.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8703054     DOI： 10.1126/science.273.5279.1219

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  159 in total

1.  M-CSF neutralization and egr-1 deficiency prevent ovariectomy-induced bone loss.

Authors:  S Cenci; M N Weitzmann; M A Gentile; M C Aisa; R Pacifici
Journal:  J Clin Invest       Date:  2000-05       Impact factor: 14.808

Review 2.  Pathways of Egr-1-mediated gene transcription in vascular biology.

Authors:  E S Silverman; T Collins
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

3.  Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells.

Authors:  Ning Lei; Leslie L Heckert
Journal:  Biol Reprod       Date:  2002-03       Impact factor: 4.285

4.  An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation.

Authors:  Suzanne B Rosenberg; Pamela L Mellon
Journal:  Mol Endocrinol       Date:  2002-06

Review 5.  GnRH signaling, the gonadotrope and endocrine control of fertility.

Authors:  Stuart P Bliss; Amy M Navratil; Jianjun Xie; Mark S Roberson
Journal:  Front Neuroendocrinol       Date:  2010-05-06       Impact factor: 8.606

6.  EGR4 displays both a cell- and intracellular-specific localization pattern in the developing murine testis.

Authors:  Cathryn A Hogarth; Debra Mitchell; Christopher Small; Michael Griswold
Journal:  Dev Dyn       Date:  2010-11       Impact factor: 3.780

7.  Expression of Egr-1 in late stage emphysema.

Authors:  W Zhang; S D Yan; A Zhu; Y S Zou; M Williams; G C Godman; B M Thomashow; M E Ginsburg; D M Stern; S F Yan
Journal:  Am J Pathol       Date:  2000-10       Impact factor: 4.307

8.  The early growth response gene Egr2 (Alias Krox20) is a novel transcriptional target of transforming growth factor-β that is up-regulated in systemic sclerosis and mediates profibrotic responses.

Authors:  Feng Fang; Kohtaro Ooka; Swati Bhattacharyya; Swati Bhattachyya; Jun Wei; Minghua Wu; Pan Du; Simon Lin; Francesco Del Galdo; Carol A Feghali-Bostwick; John Varga
Journal:  Am J Pathol       Date:  2011-05       Impact factor: 4.307

9.  Gonadotropin releasing hormone activation of the mTORC2/Rictor complex regulates actin remodeling and ERK activity in LβT2 cells.

Authors:  Brian S Edwards; William J Isom; Amy M Navratil
Journal:  Mol Cell Endocrinol       Date:  2016-09-20       Impact factor: 4.102

10.  Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium.

Authors:  Yi-Wen Liu; Wei Gao; Hui-Ling Teh; Jee-Hian Tan; Woon-Khiong Chan
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.