Literature DB >> 8701729

[Effect of DL-butylphthalide (NBP) on mouse brain energy metabolism in complete brain ischemia induced by decapitation].

Y P Feng1, D Hu, L Y Zhang.   

Abstract

The effects of NBP on gasping and brain energy metabolism after complete brain ischemia in mice subjected to decapitation were investigated. The levels of ATP, phosphocreatine (PCr) and lactate were determined by the method of Lowry. The data indicated that NBP at 112.5 or 250 mg.kg-1 sc can significantly prolong the duration of gasping and at the dose of 150 or 200 mg.kg-1 sc reduce the level of lactate and increase the levels of ATP and PCr after complete brain ischemia. The results suggest that NBP may have brain protective action and improve ischemic brain energy metabolism.

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Year:  1995        PMID： 8701729

Source DB:  PubMed          Journal:  Yao Xue Xue Bao        ISSN： 0513-4870


  9 in total

1.  DL-3-n-Butylphthalide reduces atrial fibrillation susceptibility by inhibiting atrial structural remodeling in rats with heart failure.

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Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-12-30       Impact factor: 3.000

2.  DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice.

Authors:  Yingying Zhao; Jin Hwan Lee; Dongdong Chen; Xiaohuan Gu; Asha Caslin; Jimei Li; Shan Ping Yu; Ling Wei
Journal:  Neurochem Int       Date:  2017-03-28       Impact factor: 3.921

3.  Metabolism of 6-chloro n-butyl phthalide in rat.

Authors:  S H Peng; T H Zhou
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1996 Oct-Dec       Impact factor: 2.441

4.  Protection against neurotoxicity by an autophagic mechanism.

Authors:  Kangyong Liu; Jiankang Huang; Rongfu Chen; Ting Zhang; Liwei Shen; Jiajun Yang; Xiaojiang Sun
Journal:  Braz J Med Biol Res       Date:  2012-03-22       Impact factor: 2.590

5.  L-3-n-Butylphthalide Protects HSPB8 K141N Mutation-Induced Oxidative Stress by Modulating the Mitochondrial Apoptotic and Nrf2 Pathways.

Authors:  Xiao-Dong Yang; Zhi-Dong Cen; Hai-Peng Cheng; Kai Shi; Jie Bai; Fei Xie; Hong-Wei Wu; Bei-Bei Li; Wei Luo
Journal:  Front Neurosci       Date:  2017-07-12       Impact factor: 4.677

6.  Brain cell apoptosis inhibition by butylphthalide in Alzheimer's disease model in rats.

Authors:  Fu-Xia Song; Li Wang; Hong Liu; Ying-Li Wang; Yong Zou
Journal:  Exp Ther Med       Date:  2017-04-10       Impact factor: 2.447

7.  Butylphthalide Inhibits TLR4/NF-κB Pathway by Upregulation of miR-21 to Have the Neuroprotective Effect.

Authors:  Lan Zhan; Yu Pang; Hao Jiang; Shicun Zhang; Hongwei Jin; Jing Chen; Cuiying Jia; Hongyan Guo; Zhuang Mu
Journal:  J Healthc Eng       Date:  2022-01-07       Impact factor: 2.682

8.  Protective effects of dl-3n-butylphthalide against diffuse brain injury.

Authors:  Yaning Zhao; Jianmin Li; Pan Zhang; Changxiang Chen; Shuxing Li
Journal:  Neural Regen Res       Date:  2013-10-05       Impact factor: 5.135

9.  Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging.

Authors:  Run-Zhe Liu; Chao-Xin Fan; Zhi-Lin Zhang; Xin Zhao; Yi Sun; Hui-Hui Liu; Zong-Xiu Nie; Xiao-Ping Pu
Journal:  Int J Mol Sci       Date:  2017-11-22       Impact factor: 5.923
  9 in total

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