Literature DB >> 8701471

The biology of HMG-CoA reductase: the pros of contra-regulation.

R Hampton1, D Dimster-Denk, J Rine.   

Abstract

Hydroxymethylglutaryl-CoA reductase (HMG-R) is a key enzyme in the mevalonate pathway, from which thousands of molecules are derived including cholesterol and prenyl moieties. The regulation of HMG-R is complex and includes feedback control, cross-regulation by independent bio-chemical processes and contra-regulation of separate isozymes. From studies in yeast, these separate modes of regulation can be considered in an integrated fashion.

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Year:  1996        PMID： 8701471

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  29 in total

1.  The lobster mandibular organ produces soluble and membrane-bound forms of 3-hydroxy-3-methylglutaryl-CoA reductase.

Authors:  Sheng Li; Jon A Friesen; Hong Fei; Xiang Ding; David W Borst
Journal:  Biochem J       Date:  2004-08-01       Impact factor: 3.857

Review 2.  Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway.

Authors:  Annalisa Marcuzzi; Elisa Piscianz; Claudia Loganes; Liza Vecchi Brumatti; Alessandra Knowles; Sabrine Bilel; Alberto Tommasini; Roberta Bortul; Marina Zweyer
Journal:  Int J Mol Sci       Date:  2015-12-30       Impact factor: 5.923

3.  Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae.

Authors:  Juan Rico; Ester Pardo; Margarita Orejas
Journal:  Appl Environ Microbiol       Date:  2010-07-30       Impact factor: 4.792

4.  Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae.

Authors:  K A Donald; R Y Hampton; I B Fritz
Journal:  Appl Environ Microbiol       Date:  1997-09       Impact factor: 4.792

Review 5.  Regulation of HMG-CoA reductase in mammals and yeast.

Authors:  John S Burg; Peter J Espenshade
Journal:  Prog Lipid Res       Date:  2011-07-23       Impact factor: 16.195

Review 6.  The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.

Authors:  Monika Schmoll; Christoph Dattenböck; Nohemí Carreras-Villaseñor; Artemio Mendoza-Mendoza; Doris Tisch; Mario Ivan Alemán; Scott E Baker; Christopher Brown; Mayte Guadalupe Cervantes-Badillo; José Cetz-Chel; Gema Rosa Cristobal-Mondragon; Luis Delaye; Edgardo Ulises Esquivel-Naranjo; Alexa Frischmann; Jose de Jesus Gallardo-Negrete; Monica García-Esquivel; Elida Yazmin Gomez-Rodriguez; David R Greenwood; Miguel Hernández-Oñate; Joanna S Kruszewska; Robert Lawry; Hector M Mora-Montes; Tania Muñoz-Centeno; Maria Fernanda Nieto-Jacobo; Guillermo Nogueira Lopez; Vianey Olmedo-Monfil; Macario Osorio-Concepcion; Sebastian Piłsyk; Kyle R Pomraning; Aroa Rodriguez-Iglesias; Maria Teresa Rosales-Saavedra; J Alejandro Sánchez-Arreguín; Verena Seidl-Seiboth; Alison Stewart; Edith Elena Uresti-Rivera; Chih-Li Wang; Ting-Fang Wang; Susanne Zeilinger; Sergio Casas-Flores; Alfredo Herrera-Estrella
Journal:  Microbiol Mol Biol Rev       Date:  2016-02-10       Impact factor: 11.056

7.  Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes.

Authors:  B M Lange; T Rujan; W Martin; R Croteau
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-21       Impact factor: 11.205

8.  Celastrus orbiculatus Thunb. decreases athero-susceptibility in lipoproteins and the aorta of guinea pigs fed high fat diet.

Authors:  Ying Zhang; Yanhong Si; Shutong Yao; Nana Yang; Guohua Song; Hui Sang; Dandan Zu; Xin Xu; Jianhua Wang; Shucun Qin
Journal:  Lipids       Date:  2013-03-12       Impact factor: 1.880

9.  Increased carotenoid production by the food yeast Candida utilis through metabolic engineering of the isoprenoid pathway.

Authors:  H Shimada; K Kondo; P D Fraser; Y Miura; T Saito; N Misawa
Journal:  Appl Environ Microbiol       Date:  1998-07       Impact factor: 4.792

10.  Enhancement of ganoderic acid accumulation by overexpression of an N-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum.

Authors:  Jun-Wei Xu; Yi-Ning Xu; Jian-Jiang Zhong
Journal:  Appl Environ Microbiol       Date:  2012-08-31       Impact factor: 4.792
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