Literature DB >> 8701412

Characterization of a cDNA encoding murine coagulation factor VII.

E Idusogie1, E Rosen, J P Geng, P Carmeliet, D Collen, F J Castellino.   

Abstract

The cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed from a lambda Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903 nucleotides spanning 15 bases upstream of the 5'-translation initiation codon, an open reading frame of 1338 nucleotides, 550 nucleotides downstream of the first stop codon and a 3' poly(A) tail. The translation product is composed of a 41-amino acid signal/propeptide region followed by a 405-residue mature protein. The latter is highly homologous to that of human, rabbit, bovine, Rhesus monkey, and canine fVII. All protein domains of hfVII are strictly conserved in mfVII.

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Year:  1996        PMID： 8701412

Source DB:  PubMed          Journal:  Thromb Haemost        ISSN： 0340-6245            Impact factor:   5.249


  6 in total

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Review 2.  Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis.

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Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

3.  The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor.

Authors:  Egon Persson; Jesper J Madsen; Ole H Olsen
Journal:  Protein Sci       Date:  2014-10-14       Impact factor: 6.725

4.  A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates.

Authors:  Raffaella Toso; Mirko Pinotti; Katherine A High; Eleanor S Pollak; Francesco Bernardi
Journal:  Biochem J       Date:  2002-04-15       Impact factor: 3.857

5.  Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII.

Authors:  Paris Margaritis; Valder R Arruda; Majed Aljamali; Rodney M Camire; Alexander Schlachterman; Katherine A High
Journal:  J Clin Invest       Date:  2004-04       Impact factor: 14.808

6.  Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality.

Authors:  Majed N Aljamali; Paris Margaritis; Alexander Schlachterman; Shing Jen Tai; Elise Roy; Ralph Bunte; Rodney M Camire; Katherine A High
Journal:  J Clin Invest       Date:  2008-05       Impact factor: 14.808
  6 in total

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