| Literature DB >> 8700960 |
H Nagase1, G A Bray, D A York.
Abstract
We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/Pl) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM rats and these effects were blocked by selective hepatic vagotomy. In contrast, in S5B/Pl rats fed an LF diet the responses to pyruvate and lactate were attenuated and were absent in S5B/Pl rats fed the HF diet. These data suggest that OM and S5B/Pl rats differ either in their metabolism of pyruvate and lactate or in their responses to these metabolites.Entities:
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Year: 1996 PMID： 8700960 DOI： 10.1016/0031-9384(95)02109-4
Source DB: PubMed Journal: Physiol Behav ISSN： 0031-9384