| Literature DB >> 8699182 |
W F Chiou1, J F Liao, C F Chen.
Abstract
The vasoreactivity of dehydroevodiamine (1), evodiamine (2), and rutaecarpine (3), quinazoline alkaloids isolated from Evodia rutaecarpa, to aorta smooth muscle demonstrated that they produce a vasodilatory effect on endothelium-intact rat aorta with equal potency. Compound 3 produced a full (100%) nitric oxide-dependent vasodilatation, whereas 2 and 1 produced a partially endothelium-dependent effect, 50% and 10%, respectively. At the same time, I and 2 may also act by other mechanisms, including probably an alpha1-adrenoceptor blocking action and a 5-HT antagonizing action, respectively.Entities:
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Year: 1996 PMID： 8699182 DOI： 10.1021/np960161+
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050