Literature DB >> 8699063

Interleukin-6 production by human neonatal monocytes stimulated by type III group B streptococci.

J G Vallejo1, C J Baker, M S Edwards.   

Abstract

The subcellular components of type III group B streptococci (GBS) that contribute to the host inflammatory response were determined by measuring production of the proinflammatory cytokine interleukin (IL)-6 by cord blood monocytes. Monocytes were stimulated with encapsulated (COH1) or unencapsulated (COH1-13) whole type III GBS or with purified GBS components, including type III capsular polysaccharide (III-PS), group B antigen (GB-Ag), lipoteichoic acid (LTA), or Escherichia coli lipopolysaccharide. Monocytes exposed to COH1 and COH1-13 released similar amounts of IL-6. GBS III-PS, GB-Ag, and LTA each induced IL-6. However, IL-6 release by monocytes was significantly greater after stimulation by GB-Ag than by III-PS or LTA (P < .05). Sera from 16 neonates with systemic GBS disease had IL-6 levels of 8 pg/mL to 4.28 ng/mL. GB-Ag is a potent inducer of IL-6 and may play an important role in tissue inflammation during GBS infection.

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Year:  1996        PMID： 8699063     DOI： 10.1093/infdis/174.2.332

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  10 in total

1.  Nonopsonic binding of type III Group B Streptococci to human neutrophils induces interleukin-8 release mediated by the p38 mitogen-activated protein kinase pathway.

Authors:  E A Albanyan; J G Vallejo; C W Smith; M S Edwards
Journal:  Infect Immun       Date:  2000-04       Impact factor: 3.441

2.  Levels of proinflammatory cytokines in plasma after pneumoccoccal immunization in human immunodeficiency virus type 1-infected patients.

Authors:  H Valdez; S Purvis; R Asaad; I Valerio; B E Sha; A L Landay; M M Lederman
Journal:  Clin Diagn Lab Immunol       Date:  1999-05

3.  Human monocyte receptors involved in tumor necrosis factor responses to group B streptococcal products.

Authors:  M Cuzzola; G Mancuso; C Beninati; C Biondo; C von Hunolstein; G Orefici; T Espevik; T H Flo; G Teti
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

4.  Soluble antigens from group B streptococci induce cytokine production in human blood cultures.

Authors:  C von Hunolstein; A Totolian; G Alfarone; G Mancuso; V Cusumano; G Teti; G Orefici
Journal:  Infect Immun       Date:  1997-10       Impact factor: 3.441

5.  Heat-killed Streptococcus suis capsular type 2 strains stimulate tumor necrosis factor alpha and interleukin-6 production by murine macrophages.

Authors:  M Segura; J Stankova; M Gottschalk
Journal:  Infect Immun       Date:  1999-09       Impact factor: 3.441

6.  Role of tumor necrosis factor alpha, interleukin-1beta, and interleukin-6 in a mouse model of group B streptococcal arthritis.

Authors:  L Tissi; M Puliti; R Barluzzi; G Orefici; C von Hunolstein; F Bistoni
Journal:  Infect Immun       Date:  1999-09       Impact factor: 3.441

Review 7.  Recent advances in understanding the molecular basis of group B Streptococcus virulence.

Authors:  Heather C Maisey; Kelly S Doran; Victor Nizet
Journal:  Expert Rev Mol Med       Date:  2008-09-22       Impact factor: 5.600

8.  Group B Streptococcus and Streptococcus suis capsular polysaccharides induce chemokine production by dendritic cells via Toll-like receptor 2- and MyD88-dependent and -independent pathways.

Authors:  Cynthia Calzas; Guillaume Goyette-Desjardins; Paul Lemire; Fleur Gagnon; Claude Lachance; Marie-Rose Van Calsteren; Mariela Segura
Journal:  Infect Immun       Date:  2013-06-17       Impact factor: 3.441

9.  Role of Two-Component System Response Regulator bceR in the Antimicrobial Resistance, Virulence, Biofilm Formation, and Stress Response of Group B Streptococcus.

Authors:  Ying Yang; Mingjing Luo; Haokui Zhou; Carmen Li; Alison Luk; GuoPing Zhao; Kitty Fung; Margaret Ip
Journal:  Front Microbiol       Date:  2019-01-23       Impact factor: 5.640

10.  Neonatal neutrophils stimulated by group B Streptococcus induce a proinflammatory T-helper cell bias.

Authors:  Jianguo Lin; Seema Haridas; Stephen J Barenkamp; Larissa Chioquetta Lorenset; Ashley Sang Eun Lee; Benjamin T Schroeder; Guangyong Peng; Joyce M Koenig
Journal:  Pediatr Res       Date:  2017-12-06       Impact factor: 3.756
  10 in total

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