Literature DB >> 8698750

Aromatase in breast cancer tissue--localization and relationship with reproductive status of patients.

L M Berstein1, A A Larionov, A Sh Kyshtoobaeva, K M Pozharisski, V F Semiglazov, O A Ivanova.   

Abstract

The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in different cell types, but the most intensive specific staining was found in malignant cells and it was stronger (P < 0.01) in postmenopausal patients than in patients of reproductive age.

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Year:  1996        PMID： 8698750     DOI： 10.1007/bf01187162

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  19 in total

1.  Intratumoral aromatase as a prognostic factor in human breast carcinoma.

Authors:  M C Silva; M G Rowlands; M Dowsett; B Gusterson; J A McKinna; I Fryatt; R C Coombes
Journal:  Cancer Res       Date:  1989-05-15       Impact factor: 12.701

2.  Estrogen synthesis and estradiol binding by human mammary tumors.

Authors:  R M Varela; T L Dao
Journal:  Cancer Res       Date:  1978-08       Impact factor: 12.701

Review 3.  Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways.

Authors:  R J Santen; D Leszczynski; N Tilson-Mallet; P D Feil; C Wright; A Manni; S J Santner
Journal:  Ann N Y Acad Sci       Date:  1986       Impact factor: 5.691

4.  Stromal spindle cells contain aromatase in human breast tumors.

Authors:  R J Santen; J Martel; M Hoagland; F Naftolin; L Roa; N Harada; L Hafer; R Zaino; S J Santner
Journal:  J Clin Endocrinol Metab       Date:  1994-08       Impact factor: 5.958

Review 5.  Regulation of oestradiol 17 beta hydroxysteroid dehydrogenase in breast tissues: the role of growth factors.

Authors:  M J Reed; A Singh; M W Ghilchik; N G Coldham; A Purohit
Journal:  J Steroid Biochem Mol Biol       Date:  1991-11       Impact factor: 4.292

6.  A reassessment of the role of breast tumor aromatization.

Authors:  H L Bradlow
Journal:  Cancer Res       Date:  1982-08       Impact factor: 12.701

7.  The intracellular control of aromatase activity by 5 alpha-reduced androgens in human breast carcinoma cells in culture.

Authors:  E Perel; K H Stolee; L Kharlip; M E Blackstein; D W Killinger
Journal:  J Clin Endocrinol Metab       Date:  1984-03       Impact factor: 5.958

8.  Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue.

Authors:  A A van Landeghem; J Poortman; M Nabuurs; J H Thijssen
Journal:  Cancer Res       Date:  1985-06       Impact factor: 12.701

9.  Aromatase activity in normal breast and breast tumor tissues: in vivo and in vitro studies.

Authors:  V H James; J M McNeill; L C Lai; C J Newton; M W Ghilchik; M J Reed
Journal:  Steroids       Date:  1987 Jul-Sep       Impact factor: 2.668

10.  Aromatase activity and estradiol in human breast cancer: its relationship to estradiol and epidermal growth factor receptors and to tumor-node-metastasis staging.

Authors:  P Bolufer; E Ricart; A Lluch; C Vazquez; A Rodriguez; A Ruiz; F Llopis; J Garcia-Conde; R Romero
Journal:  J Clin Oncol       Date:  1992-03       Impact factor: 44.544
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  2 in total

1.  Preparation of a novel antiserum to aromatase with high affinity and specificity: Its clinicopathological significance on breast cancer tissue.

Authors:  Naoki Kanomata; Shiro Matsuura; Tsunehisa Nomura; Junichi Kurebayashi; Taisuke Mori; Jo Kitawaki; Takuya Moriya
Journal:  PLoS One       Date:  2017-05-10       Impact factor: 3.240

2.  Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breast.

Authors:  Zhenhuan Zhang; Hiroko Yamashita; Tatsuya Toyama; Yoko Omoto; Hiroshi Sugiura; Yasuo Hara; Xueqing Wu; Shunzo Kobayashi; Hirotaka Iwase
Journal:  Breast Cancer Res       Date:  2003-10-09       Impact factor: 6.466
  2 in total

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