| Literature DB >> 8698642 |
R D Cooper1, N J Snyder, M J Zweifel, M A Staszak, S C Wilkie, T I Nicas, D L Mullen, T F Butler, M J Rodriguez, B E Huff, R C Thompson.
Abstract
Reductive alkylation of the A82846 family of glycopeptide antibiotics has the potential of producing seven products. N-Alkylation of the disaccharide amino function can be accomplished selectively, and offers the greatest increase in antibacterial activity. Products resulting from N-alkylation of LY264826 (A82846B) provide the most potent derivatives as compared to other members of this class of antibiotics. Two of these derivatives, LY307599 and LY333328 are approximately 500 times more active than vancomycin against vancomycin-resistant enterococci.Entities:
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Year: 1996 PMID： 8698642 DOI： 10.7164/antibiotics.49.575
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649