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Literature DB >> 8698517

Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates.

Abstract

The O-polysaccharide moiety of Burkholderia pseudomallei 319a lipopolysaccharide was covalently linked to flagellin protein isolated from the same strain. A glycoconjugate incorporating adipic acid dihydrazide as a spacer molecule elicited high-titer immunoglobulin G responses to both the protein and carbohydrate components of the construct. This immunoglobulin G was capable of protecting diabetic rats from challenge with a heterologous B. pseudomallei strain.

Entities: Chemical Disease Species

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Year: 1996 PMID： 8698517 PMCID： PMC174148 DOI： 10.1128/iai.64.7.2824-2828.1996

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

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