Literature DB >> 8696010

Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection.

L L Johnson1, P C Sayles.   

Abstract

That strong cytolytic activity of natural killer (NK) cells is neither necessary nor sufficient for defense against acute Toxoplasma gondii infection is demonstrated. T. gondii-infected anti-interferon (IFN)-gamma-treated mice and IFN-gamma gene knockout mice died despite good induction of NK activity, while infected beige mice, deficient in NK cytolytic activity, survived.

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Year:  1995        PMID： 8696010

Source DB:  PubMed          Journal:  Nat Immun        ISSN： 1018-8916


  4 in total

1.  L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase.

Authors:  Suwako Fujigaki; Kuniaki Saito; Masao Takemura; Naoya Maekawa; Yasuhiro Yamada; Hisayasu Wada; Mitsuru Seishima
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

2.  Intranasal interleukin-12 treatment for protection against respiratory infection with the Francisella tularensis live vaccine strain.

Authors:  Nathalie S Duckett; Sofia Olmos; Douglas M Durrant; Dennis W Metzger
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

3.  Exacerbated susceptibility to infection-stimulated immunopathology in CD1d-deficient mice.

Authors:  Stephen T Smiley; Paula A Lanthier; Kevin N Couper; Frank M Szaba; Jonathan E Boyson; Wangxue Chen; Lawrence L Johnson
Journal:  J Immunol       Date:  2005-06-15       Impact factor: 5.422

4.  Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii.

Authors:  T M Scharton-Kersten; G Yap; J Magram; A Sher
Journal:  J Exp Med       Date:  1997-04-07       Impact factor: 14.307
  4 in total

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