Literature DB >> 8694839

Autoantibody against Na+/I- symporter in the sera of patients with autoimmune thyroid disease.

T Endo1, T Kogai, M Nakazato, T Saito, M Kaneshige, T Onaya.   

Abstract

Using recombinant rat Na+/I- symporter (NaIS) protein, we have immunochemically searched for the autoantibody in the sera from patients with autoimmune thyroid disease. We found that 22 out of 26 sera (84%) from patients with Graves' disease and 3 out of 20 sera (15%) from patients with Hashimoto's thyroiditis recognized it. By Western blot, these IgGs reacted with 80 kDa protein in FRTL-5 cell membrane, which co-migrated with the band stained by rabbit antibody toward NaIS. These results indicate that autoantibody against NaIS, newly identified antibody, frequently exists in patients with autoimmune thyroid disease, especially in Graves' disease.

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Year:  1996        PMID： 8694839     DOI： 10.1006/bbrc.1996.0989

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Homologies of the thyroid sodium-iodide symporter with bacterial and viral proteins.

Authors:  S Benvenga; S Alesci; F Trimarchi; A Facchiano
Journal:  J Endocrinol Invest       Date:  1999 Jul-Aug       Impact factor: 4.256

2.  Identification of antigenic domains on the human sodium-iodide symporter which are recognized by autoantibodies from patients with autoimmune thyroid disease.

Authors:  E H Kemp; E A Waterman; R A Ajjan; K A Smith; P F Watson; M E Ludgate; A P Weetman
Journal:  Clin Exp Immunol       Date:  2001-06       Impact factor: 4.330

3.  Biased signaling by thyroid-stimulating hormone receptor-specific antibodies determines thyrocyte survival in autoimmunity.

Authors:  Syed A Morshed; Risheng Ma; Rauf Latif; Terry F Davies
Journal:  Sci Signal       Date:  2018-01-23       Impact factor: 8.192

Review 4.  Delineating the autoimmune mechanisms in Graves' disease.

Authors:  Syed A Morshed; Rauf Latif; Terry F Davies
Journal:  Immunol Res       Date:  2012-12       Impact factor: 2.829

5.  Characterization of the thyroid Na+/I- symporter with an anti-COOH terminus antibody.

Authors:  O Levy; G Dai; C Riedel; C S Ginter; E M Paul; A N Lebowitz; N Carrasco
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-27       Impact factor: 11.205

6.  Thyroid iodide transporter: local sequence homologies with thyroid autoantigens.

Authors:  S Benvenga; L Bartolone; F Trimarchi
Journal:  J Endocrinol Invest       Date:  1997-10       Impact factor: 4.256

7.  Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas.

Authors:  T Saito; T Endo; A Kawaguchi; M Ikeda; R Katoh; A Kawaoi; A Muramatsu; T Onaya
Journal:  J Clin Invest       Date:  1998-04-01       Impact factor: 14.808

8.  Rescue of thyroid cells from antibody induced cell death via induction of autophagy.

Authors:  Syed Morshed; Rauf Latif; Terry F Davies
Journal:  J Autoimmun       Date:  2021-11-18       Impact factor: 7.094

9.  In vivo monitoring of transfected DNA, gene expression kinetics, and cellular immune responses in mice immunized with a human NIS gene-expressing plasmid.

Authors:  Hye-Youn Son; Yong-Hyun Jeon; June-Key Chung; Chul-Woo Kim
Journal:  Int J Immunopathol Pharmacol       Date:  2016-09-09       Impact factor: 3.219

10.  Natural autoantibodies to the gonadotropin-releasing hormone receptor in polycystic ovarian syndrome.

Authors:  Lisa-Marie Sattler; Hanna A Schniewind; Waldemar B Minich; Christoph W Haudum; Petra Niklowitz; Julia Münzker; Gábor L Kovács; Thomas Reinehr; Barbara Obermayer-Pietsch; Lutz Schomburg
Journal:  PLoS One       Date:  2021-04-02       Impact factor: 3.240
  10 in total

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