Literature DB >> 8692869

Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin.

D Höfer1, B Püschel, D Drenckhahn.   

Abstract

The alpha-subunit of the trimeric G-protein complex specific for taste receptor cells of the tongue, alpha-gustducin, is described here to be also expressed in the stomach and intestine. The alpha-gustducin-containing cells were identified as brush cells that are scattered throughout the surface epithelium of the gut and share structural features of taste receptor cells of the tongue. These findings provide clues to the long-sought molecular and cellular basis for chemoreception in the gut.

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Year:  1996        PMID： 8692869      PMCID： PMC39077          DOI： 10.1073/pnas.93.13.6631

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Identification of brush cells in the alimentary and respiratory system by antibodies to villin and fimbrin.

Authors:  D Höfer; D Drenckhahn
Journal:  Histochemistry       Date:  1992-11

2.  Brush cells of the mouse gallbladder. A correlative light- and electron-microscopical study.

Authors:  L Luciano; E Reale
Journal:  Cell Tissue Res       Date:  1990-11       Impact factor: 5.249

3.  Gustducin is a taste-cell-specific G protein closely related to the transducins.

Authors:  S K McLaughlin; P J McKinnon; R F Margolskee
Journal:  Nature       Date:  1992-06-18       Impact factor: 49.962

4.  Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCl in rats.

Authors:  H Kitagawa; F Takeda; H Kohei
Journal:  J Pharmacol Exp Ther       Date:  1990-06       Impact factor: 4.030

Review 5.  Intestinal chemosensitivity.

Authors:  N Mei
Journal:  Physiol Rev       Date:  1985-04       Impact factor: 37.312

6.  Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide.

Authors:  Y Cetin; M Kuhn; H Kulaksiz; K Adermann; G Bargsten; D Grube; W G Forssmann
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

7.  Stomach NO synthesis.

Authors:  N Benjamin; F O'Driscoll; H Dougall; C Duncan; L Smith; M Golden; H McKenzie
Journal:  Nature       Date:  1994-04-07       Impact factor: 49.962

8.  Intrinsic source of stomach NO.

Authors:  P Kugler; D Drenckhahn
Journal:  Nature       Date:  1994-07-07       Impact factor: 49.962

9.  The cells of the rat gastric groove and cardia. An ultrastructural and carbohydrate histochemical study, with special reference to the fibrillovesicular cells.

Authors:  W Wattel; J J Geuze
Journal:  Cell Tissue Res       Date:  1978-01-31       Impact factor: 5.249

10.  Structural features of the apical and tubulovesicular membranes of rodent small intestinal tuft cells.

Authors:  J S Trier; C H Allan; M A Marcial; J L Madara
Journal:  Anat Rec       Date:  1987-09
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  131 in total

1.  Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells.

Authors:  S Vincent Wu; Nora Rozengurt; Moon Yang; Steven H Young; James Sinnett-Smith; Enrique Rozengurt
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205

2.  Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery.

Authors:  Maartje C P Geraedts; Tatsuyuki Takahashi; Stephan Vigues; Michele L Markwardt; Andongfac Nkobena; Renee E Cockerham; Andras Hajnal; Cedrick D Dotson; Mark A Rizzo; Steven D Munger
Journal:  Am J Physiol Endocrinol Metab       Date:  2012-06-05       Impact factor: 4.310

3.  Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice.

Authors:  Anthony Sclafani; Damien S Glass; Robert F Margolskee; John I Glendinning
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-10-06       Impact factor: 3.619

4.  Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration.

Authors:  Thomas E Finger; Bärbel Böttger; Anne Hansen; Karl T Anderson; Hessamedin Alimohammadi; Wayne L Silver
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-11       Impact factor: 11.205

Review 5.  Gastrointestinal chemosensation: chemosensory cells in the alimentary tract.

Authors:  H Breer; J Eberle; C Frick; D Haid; P Widmayer
Journal:  Histochem Cell Biol       Date:  2012-04-24       Impact factor: 4.304

Review 6.  Recent progress in histochemistry and cell biology.

Authors:  Stefan Hübner; Athina Efthymiadis
Journal:  Histochem Cell Biol       Date:  2012-02-25       Impact factor: 4.304

Review 7.  Recent advances in gut nutrient chemosensing.

Authors:  C A Nguyen; Y Akiba; J D Kaunitz
Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530

8.  Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine.

Authors:  Weiwei Lei; Wenwen Ren; Makoto Ohmoto; Joseph F Urban; Ichiro Matsumoto; Robert F Margolskee; Peihua Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-07       Impact factor: 11.205

Review 9.  T1R and T2R receptors: the modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitus.

Authors:  Cedrick D Dotson; Stephan Vigues; Nanette I Steinle; Steven D Munger
Journal:  Curr Opin Investig Drugs       Date:  2010-04

Review 10.  The mysterious pulmonary brush cell: a cell in search of a function.

Authors:  Lynne Reid; Barbara Meyrick; Veena B Antony; Ling-Yi Chang; James D Crapo; Herbert Y Reynolds
Journal:  Am J Respir Crit Care Med       Date:  2005-04-07       Impact factor: 21.405
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