Literature DB >> 8692860

Separation of the transcriptional coactivator and antirepression functions of transcription factor IIA.

D MA1, I Olave, A Merino, D Reinberg.   

Abstract

Human transcription factor IIA (TFIIA) is composed of three subunits (alpha, beta, and gamma). TFIIA interacts with the TATA-box binding protein and can overcome repression of transcription. TFIIA was found to be necessary for VP16-mediated transcriptional activation through a coactivator function. We have separated the coactivator and antirepression activities of TFIIA. A TFIIA lacking the alpha subunit was isolated from HeLa cells. This "mini-TFIIA" interacts with the TATA-box binding protein and can overcome repression of transcription, but it is defective in transcriptional coactivator function.

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Year:  1996        PMID： 8692860      PMCID： PMC39068          DOI： 10.1073/pnas.93.13.6583

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  53 in total

Review 1.  Commitment and activation at pol II promoters: a tail of protein-protein interactions.

Authors:  B Lewin
Journal:  Cell       Date:  1990-06-29       Impact factor: 41.582

2.  Mechanism of transcriptional activation by Sp1: evidence for coactivators.

Authors:  B F Pugh; R Tjian
Journal:  Cell       Date:  1990-06-29       Impact factor: 41.582

Review 3.  Activators and targets.

Authors:  M Ptashne; A A Gann
Journal:  Nature       Date:  1990-07-26       Impact factor: 49.962

4.  Cloning of a transcriptionally active human TATA binding factor.

Authors:  C C Kao; P M Lieberman; M C Schmidt; Q Zhou; R Pei; A J Berk
Journal:  Science       Date:  1990-06-29       Impact factor: 47.728

5.  Functional domains and upstream activation properties of cloned human TATA binding protein.

Authors:  M G Peterson; N Tanese; B F Pugh; R Tjian
Journal:  Science       Date:  1990-06-29       Impact factor: 47.728

6.  Five intermediate complexes in transcription initiation by RNA polymerase II.

Authors:  S Buratowski; S Hahn; L Guarente; P A Sharp
Journal:  Cell       Date:  1989-02-24       Impact factor: 41.582

7.  A human RNA polymerase II complex associated with SRB and DNA-repair proteins.

Authors:  E Maldonado; R Shiekhattar; M Sheldon; H Cho; R Drapkin; P Rickert; E Lees; C W Anderson; S Linn; D Reinberg
Journal:  Nature       Date:  1996-05-02       Impact factor: 49.962

8.  A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA-binding activity.

Authors:  C S Parker; J Topol
Journal:  Cell       Date:  1984-02       Impact factor: 41.582

9.  Factors involved in specific transcription by mammalian RNA polymerase II: purification, genetic specificity, and TATA box-promoter interactions of TFIID.

Authors:  N Nakajima; M Horikoshi; R G Roeder
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

10.  Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID).

Authors:  A Hoffman; E Sinn; T Yamamoto; J Wang; A Roy; M Horikoshi; R G Roeder
Journal:  Nature       Date:  1990-07-26       Impact factor: 49.962
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  16 in total

1.  The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter.

Authors:  T C Kuhlman; H Cho; D Reinberg; N Hernandez
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

2.  TFIIB recognition elements control the TFIIA-NC2 axis in transcriptional regulation.

Authors:  Wensheng Deng; Barbora Malecová; Thomas Oelgeschläger; Stefan G E Roberts
Journal:  Mol Cell Biol       Date:  2008-12-29       Impact factor: 4.272

3.  Identification of a transcriptional activation domain in yeast repressor activator protein 1 (Rap1) using an altered DNA-binding specificity variant.

Authors:  Amanda N Johnson; P Anthony Weil
Journal:  J Biol Chem       Date:  2017-02-14       Impact factor: 5.157

4.  The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.

Authors:  S Akoulitchev; D Reinberg
Journal:  Genes Dev       Date:  1998-11-15       Impact factor: 11.361

5.  The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription.

Authors:  I Olave; D Reinberg; L D Vales
Journal:  Genes Dev       Date:  1998-06-01       Impact factor: 11.361

Review 6.  Molecular genetics of the RNA polymerase II general transcriptional machinery.

Authors:  M Hampsey
Journal:  Microbiol Mol Biol Rev       Date:  1998-06       Impact factor: 11.056

Review 7.  Considerations of transcriptional control mechanisms: do TFIID-core promoter complexes recapitulate nucleosome-like functions?

Authors:  A Hoffmann; T Oelgeschläger; R G Roeder
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

8.  Association of transcription factor IIA with TATA binding protein is required for transcriptional activation of a subset of promoters and cell cycle progression in Saccharomyces cerevisiae.

Authors:  J Ozer; L E Lezina; J Ewing; S Audi; P M Lieberman
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

9.  TFIIA interacts with TFIID via association with TATA-binding protein and TAF40.

Authors:  S M Kraemer; R T Ranallo; R C Ogg; L A Stargell
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

10.  TAFII-independent activation mediated by human TBP in the presence of the positive cofactor PC4.

Authors:  S Y Wu; E Kershnar; C M Chiang
Journal:  EMBO J       Date:  1998-08-03       Impact factor: 11.598
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