Submassive necrosis of liver of Channa gachua, a fresh water fish during experimental alloxan diabetes.

An extensive change in the liver architecture leading to submassive necrosis has been observed in Channa gachua toxicated with alloxan. An intramuscular dosage of 10 mg/kg of the toxicant mobilized liver glycogen after 4 h of application leading to hyperglycaemia of blood. The serial changes occurring in the liver have been discussed at intervals of 24, 48, 96 and 100 h, when the fish reached to comasate condition and finally died.