Y Okusa1, T Ichikura, S Tamakuma. 1. First Department of Surgery, National Defense Medical College, Tokorozawa, Japan.
Abstract
UNLABELLED: Purpose of this study was to assess the role of p53 gene and tumor proliferating activity in familial clustering of gastric cancer. MATERIALS AND METHODS: Among 344 patients who underwent resections for gastric cancer, 10 patients had two or more gastric cancer-affected, first-degree relatives. We classified them as the group of gastric cancer with family history (FGC). Eighty-seven patients with gastric cancer who had no relatives with any malignant neoplasm were classified as the sporadic group. The paraffin-embedded specimens were stained immuno-histochemically using monoclonal antibodies against the p53 product and proliferating cell nuclear antigen (PCNA). RESULTS: There was no significant difference in any clinicopathologic factor and the PCNA labeling index between the two groups. Staining for the p53 product was positive in 80% of the FGC group and in 38% of the sporadic group (P < 0.05). CONCLUSION: Our study suggests that overexpression of p53 protein is one of the familial factors that correlates with carcinogenesis in the stomach.
UNLABELLED: Purpose of this study was to assess the role of p53 gene and tumor proliferating activity in familial clustering of gastric cancer. MATERIALS AND METHODS: Among 344 patients who underwent resections for gastric cancer, 10 patients had two or more gastric cancer-affected, first-degree relatives. We classified them as the group of gastric cancer with family history (FGC). Eighty-seven patients with gastric cancer who had no relatives with any malignant neoplasm were classified as the sporadic group. The paraffin-embedded specimens were stained immuno-histochemically using monoclonal antibodies against the p53 product and proliferating cell nuclear antigen (PCNA). RESULTS: There was no significant difference in any clinicopathologic factor and the PCNA labeling index between the two groups. Staining for the p53 product was positive in 80% of the FGC group and in 38% of the sporadic group (P < 0.05). CONCLUSION: Our study suggests that overexpression of p53 protein is one of the familial factors that correlates with carcinogenesis in the stomach.