Literature DB >> 8691094

Involvement of IGF-II in human cancer.

J A Toretsky1, L J Helman.   

Abstract

IGF-II is a regulatory peptide which appears to be involved significantly in the progression of many tumors, while minimally involved in post-fetal non-tumor tissue. Interruption of IGF-II pathways therefore offers the possibility of tumor control with a high therapeutic index. Investigators should continue to evaluate tumors for the involvement of IGF-II as well as investigate clinically relevant means of disrupting those pathways.

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Year:  1996        PMID： 8691094     DOI： 10.1677/joe.0.1490367

Source DB:  PubMed          Journal:  J Endocrinol        ISSN： 0022-0795            Impact factor:   4.286


  32 in total

1.  The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.

Authors:  Matthew J Martin; Nataliya Melnyk; Michelle Pollard; Mary Bowden; Hon Leong; Thomas J Podor; Martin Gleave; Poul H B Sorensen
Journal:  Mol Cell Biol       Date:  2006-03       Impact factor: 4.272

2.  Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system.

Authors:  I Ueki; G T Ooi; M L Tremblay; K R Hurst; L A Bach; Y R Boisclair
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

3.  Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.

Authors:  J L Varga; A V Schally; V J Csernus; M Zarándi; G Halmos; K Groot; Z Rékási
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

4.  Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells.

Authors:  Wolfgang Hartmann; Arend Koch; Hendrik Brune; Anke Waha; Ulrich Schüller; Indra Dani; Dorota Denkhaus; Wilhelma Langmann; Udo Bode; Otmar D Wiestler; Karl Schilling; Torsten Pietsch
Journal:  Am J Pathol       Date:  2005-04       Impact factor: 4.307

5.  Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis.

Authors:  Oliver Bracko; Tatjana Singer; Stefan Aigner; Marlen Knobloch; Beate Winner; Jasodhara Ray; Gregory D Clemenson; Hoonkyo Suh; Sebastien Couillard-Despres; Ludwig Aigner; Fred H Gage; Sebastian Jessberger
Journal:  J Neurosci       Date:  2012-03-07       Impact factor: 6.167

6.  Development of targeted therapy for a broad spectrum of solid tumors mediated by a double promoter plasmid expressing diphtheria toxin under the control of IGF2-P4 and IGF2-P3 regulatory sequences.

Authors:  Doron Amit; Sagi Tamir; Abraham Hochberg
Journal:  Int J Clin Exp Med       Date:  2013-01-26

7.  Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor.

Authors:  Dirk Prawitt; Thorsten Enklaar; Barbara Gärtner-Rupprecht; Christian Spangenberg; Monika Oswald; Ekkehart Lausch; Peter Schmidtke; Dirk Reutzel; Stephan Fees; Rob Lucito; Maria Korzon; Izabela Brozek; Janusz Limon; David E Housman; Jerry Pelletier; Bernhard Zabel
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-02       Impact factor: 11.205

8.  The insulin-like growth factor system: towards clinical applications.

Authors:  Leon A Bach
Journal:  Clin Biochem Rev       Date:  2004-08

Review 9.  Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases.

Authors:  Y Wang; R G MacDonald; G Thinakaran; S Kar
Journal:  Mol Neurobiol       Date:  2016-03-19       Impact factor: 5.590

10.  Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone.

Authors:  H Kiaris; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205
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