Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The role of calcium in the regulation of apoptosis.

Literature DB >> 8691060

The role of calcium in the regulation of apoptosis.

Abstract

The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanisms may also he involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeostasis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified. This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death.

Entities: Chemical Species

Mesh：

Substances：

Year: 1996 PMID： 8691060

Source DB: PubMed Journal: J Leukoc Biol ISSN： 0741-5400 Impact factor: 4.962

Keyword Cloud
Cited

34 in total

1. Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin.

Authors: J Lotem; R Kama; L Sachs
Journal: Proc Natl Acad Sci U S A Date: 1999-10-12 Impact factor: 11.205

2. Role of Ca2+ in apoptosis evoked by human amylin in pancreatic islet beta-cells.

Authors: J Z Bai; E L Saafi; S Zhang; G J Cooper
Journal: Biochem J Date: 1999-10-01 Impact factor: 3.857

Review 3. Neural activity and survival in the developing nervous system.

Authors: S Mennerick; C F Zorumski
Journal: Mol Neurobiol Date: 2000 Aug-Dec Impact factor: 5.590

4. Protection against hydrogen peroxide cytotoxicity in rat-1 fibroblasts provided by the oncoprotein Bcl-2: maintenance of calcium homoeostasis is secondary to the effect of Bcl-2 on cellular glutathione.

Authors: M M Rimpler; U Rauen; T Schmidt; T Möröy; H de Groot
Journal: Biochem J Date: 1999-05-15 Impact factor: 3.857

10. The protection of hepatocyte cells from the effects of oxidative stress by treatment with vitamin E in conjunction with DTT.

Authors: Jen-Hsiang Tsai; Haw-Wen Chen; Yi-Wan Chen; Jer-Yuh Liu; Chong-Kuei Lii
Journal: J Biomed Biotechnol Date: 2010-05-18

The role of calcium in the regulation of apoptosis.

1. Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin.

2. Role of Ca2+ in apoptosis evoked by human amylin in pancreatic islet beta-cells.

Review 3. Neural activity and survival in the developing nervous system.

4. Protection against hydrogen peroxide cytotoxicity in rat-1 fibroblasts provided by the oncoprotein Bcl-2: maintenance of calcium homoeostasis is secondary to the effect of Bcl-2 on cellular glutathione.

5. Diallyldisulfide-induced calcium response of HL-60 human promyelocytes.

6. Neuroprotective effects of genistein in VSC4.1 motoneurons exposed to activated microglial cytokines.

7. The role of Ca2+ on the DADS-induced apoptosis in mouse-rat hybrid retina ganglion cells (N18).

8. Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis.

9. Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells.

10. The protection of hepatocyte cells from the effects of oxidative stress by treatment with vitamin E in conjunction with DTT.