Literature DB >> 8690785

Proadrenomedullin NH2-terminal 20 peptide inhibits the voltage-gated Ca2+ channel current through a pertussis toxin-sensitive G protein in rat pheochromocytoma-derived PC 12 cells.

K Takano1, N Yamashita, T Fujita.   

Abstract

The effect of proadrenomedullin NH2-terminal 20 peptide (PAMP) on the voltage-gated Ca2+ channel current was investigated using the perforated whole-cell clamp technique on NGF-treated PC12 cells. PAMP inhibited the Ba2+ current through N-type Ca2+ channels in a concentration dependent manner. Injection of GDPbetaS into the cell abolished the inhibition while injection of GTPgammaS into the cell made the inhibition irreversible, indicating that the PAMP-induced inhibition of the voltage-gated Ca2+ channel was mediated by a G protein. The inhibition was abolished by pretreating the cells with pertussis toxin, indicating that a pertussis toxin-sensitive G protein was involved in the signal transduction mechanism of PAMP. The present study revealed that the inhibition of catecholamine secretion from sympathetic nerve endings by PAMP could be explained by the inhibition of N-type Ca2+ channels, which was mediated by pertussis toxin-sensitive G protein.

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Year:  1996        PMID： 8690785      PMCID： PMC507394          DOI： 10.1172/JCI118758

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  15 in total

Review 1.  Receptor-mediated regulation of calcium channels and neurotransmitter release.

Authors:  R J Miller
Journal:  FASEB J       Date:  1990-12       Impact factor: 5.191

2.  Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons.

Authors:  L D Hirning; A P Fox; E W McCleskey; B M Olivera; S A Thayer; R J Miller; R W Tsien
Journal:  Science       Date:  1988-01-01       Impact factor: 47.728

3.  Proadrenomedullin NH(2)-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings.

Authors:  T Shimosawa; Y Ito; K Ando; K Kitamura; K Kangawa; T Fujita
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

4.  Inhibition of the interaction of G protein G(o) with calcium channels by the calcium channel beta-subunit in rat neurones.

Authors:  V Campbell; N S Berrow; E M Fitzgerald; K Brickley; A C Dolphin
Journal:  J Physiol       Date:  1995-06-01       Impact factor: 5.182

5.  Differential expression by nerve growth factor of two types of Ca2+ channels in rat phaeochromocytoma cell lines.

Authors:  M M Usowicz; H Porzig; C Becker; H Reuter
Journal:  J Physiol       Date:  1990-07       Impact factor: 5.182

6.  Functional expression of dihydropyridine-insensitive calcium channels during PC12 cell differentiation by nerve growth factor (NGF), oncogenic ras, or src tyrosine kinase.

Authors:  D M Rausch; D L Lewis; J L Barker; L E Eiden
Journal:  Cell Mol Neurobiol       Date:  1990-06       Impact factor: 5.046

7.  Neuronal differentiation of Ca2+ channel by nerve growth factor.

Authors:  M Takahashi; H Tsukui; H Hatanaka
Journal:  Brain Res       Date:  1985-08-26       Impact factor: 3.252

8.  Immunoreactive proadrenomedullin N-terminal 20 peptide in human tissue, plasma and urine.

Authors:  H Washimine; K Kitamura; Y Ichiki; Y Yamamoto; K Kangawa; H Matsuo; T Eto
Journal:  Biochem Biophys Res Commun       Date:  1994-07-29       Impact factor: 3.575

9.  Proadrenomedullin N-terminal 20 peptide (PAMP), an endogenous anticholinergic peptide: its exocytotic secretion and inhibition of catecholamine secretion in adrenal medulla.

Authors:  F Katoh; K Kitamura; H Niina; R Yamamoto; H Washimine; K Kangawa; Y Yamamoto; H Kobayashi; T Eto; A Wada
Journal:  J Neurochem       Date:  1995-01       Impact factor: 5.372

10.  Muscarinic activation of ionic currents measured by a new whole-cell recording method.

Authors:  R Horn; A Marty
Journal:  J Gen Physiol       Date:  1988-08       Impact factor: 4.086
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  5 in total

1.  Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells.

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Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-07-05       Impact factor: 6.237

2.  Effect of vasoactive peptides in Tetrahymena: chemotactic activities of adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP) and calcitonin gene-related peptide (CGRP).

Authors:  László Kőhidai; Katalin Tóth; Paul Samotik; Kiran Ranganathan; Orsolya Láng; Miklós Tóth; Heikki Ruskoaho
Journal:  Mol Cell Biochem       Date:  2015-10-19       Impact factor: 3.396

3.  Interleukin 1beta modulates rat subfornical organ neurons as a result of activation of a non-selective cationic conductance.

Authors:  Sheana E Desson; Alastair Victor Ferguson
Journal:  J Physiol       Date:  2003-07-01       Impact factor: 5.182

4.  Proadrenomedullin N-terminal 20 peptide inhibits adrenocorticotropin secretion from cultured pituitary cells, possibly via activation of a potassium channel.

Authors:  W K Samson; T C Murphy; Z T Resch
Journal:  Endocrine       Date:  1998-12       Impact factor: 3.925

5.  The effect of adrenomedullin and proadrenomedullin N-terminal 20 peptide on angiotensin II induced vascular smooth muscle cell proliferation.

Authors:  Jian Ma; Yinglu Feng; Zaiquan Li; Chaoshu Tang
Journal:  Iran J Basic Med Sci       Date:  2016-01       Impact factor: 2.699
  5 in total

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