Literature DB >> 8689613

Loss of an X chromosome in aggressive angiomyxoma of female soft parts: a case report.

M B Kenny-Moynihan1, J Hagen, B Richman, D G McIntosh, J A Bridge.   

Abstract

Cytogenetic analysis of an aggressive angiomyxoma of the vulvar region of a 16-year-old female revealed loss of one X chromosome (45,X,-X) in eight of 20 metaphase cells analyzed. Fluorescence in situ hybridization (FISH) performed on disaggregated cells from paraffin embedded lesional tissue confirmed loss of an X chromosome in 31% of cells. Cytogenetic analysis performed on peripheral blood showed a normal chromosomal complement (46,XX). Thus, loss of one X chromosome appears to be confined to the neoplasm. This anomaly has not been previously described in aggressive angiomyxoma.

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Year:  1996        PMID： 8689613     DOI： 10.1016/0165-4608(95)00350-9

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  6 in total

1.  Deregulation of HMGA2 in an aggressive angiomyxoma with t(11;12)(q23;q15).

Authors:  Francesca Micci; Ioannis Panagopoulos; Bodil Bjerkehagen; Sverre Heim
Journal:  Virchows Arch       Date:  2006-03-28       Impact factor: 4.064

2.  Aggressive angiomyxoma: a clinicopathological and immunohistochemical study of 11 cases with long-term follow-up.

Authors:  J F Graadt van Roggen; J A M van Unnik; I H Briaire-de Bruijn; P C W Hogendoorn
Journal:  Virchows Arch       Date:  2004-11-03       Impact factor: 4.064

3.  Fusion of High Mobility Group AT-hook 2 Gene (HMGA2) With the Chromosome 12 Open Reading Frame 42 Gene (C12orf42) in an Aggressive Angiomyxoma With del(12)(q14q23) as the Sole Cytogenetic Anomaly.

Authors:  Ioannis Panagopoulos; Ludmila Gorunova; Kristin Andersen; Ingvild Lobmaier; Francesca Micci; Sverre Heim
Journal:  Cancer Genomics Proteomics       Date:  2022 Sep-Oct       Impact factor: 3.395

Review 4.  Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature.

Authors:  Neil J Rawlinson; William W West; Marilu Nelson; Julia A Bridge
Journal:  Cancer Genet Cytogenet       Date:  2008-03

5.  Mutation of an X chromosome in aggressive angiomyxoma: Report of a case and review of the literature.

Authors:  Xiu Xiu Jiang; Lang Hong Qian; Hong Kai Xu; Ming Shi Lv; Mei Hang Jin
Journal:  Gynecol Oncol Case Rep       Date:  2011-12-13

6.  Aggressive Angiomyxoma in the Scrotum: A Case Series and Literature Review.

Authors:  Juan Sun; Peng H Lian; Zi X Ye; De X Dong; Zhi G Ji; Jin Wen; Han Z Li
Journal:  Front Surg       Date:  2022-03-02
  6 in total

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