| Literature DB >> 8688839 |
B F Morel1, M A Burke, J Kalagnanam, S A McCarthy, D J Tweardy, P A Morel.
Abstract
The cytokines are the information superhighway of the immune system. They are an important component of the integrated behavior of the system. In order to be able to have a good understanding of the immune system, we must be able to model the effect of cytokines and their combined effect. This work is a step in that direction. We study the combined effect of two cytokines: interleukin-2 (IL-2) and interleukin-4 (IL-4) on some cells of the immune system. Interleukin-2 and interleukin-4 are important growth and differentiation factors for B and T cells. Interleukin-4 antagonizes the effect of interleukin-2 on B cells and some T cells while it synergizes with interleukin-2 on other T cells. We build a mathematical model of the interaction of both cytokines on T and B cells as a building block toward a model of the Th1/Th2 cross-regulation. The response of a given cell to the combination of interleukin-2 and interleukin-4 is shown to involve competing dynamical effects which can lead to either antagonistic or synergistic combined effect.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8688839 DOI： 10.1007/bf02460597
Source DB: PubMed Journal: Bull Math Biol ISSN： 0092-8240 Impact factor: 1.758