Literature DB >> 8688168

Acetogenins from Annonaceae, inhibitors of mitochondrial complex I.

M C Zafra-Polo1, M C González, E Estornell, S Sahpaz, D Cortes.   

Abstract

One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).

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Year:  1996        PMID： 8688168     DOI： 10.1016/0031-9422(95)00836-5

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  24 in total

1.  Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I.

Authors:  Nuria de Pedro; Bastien Cautain; Angeles Melguizo; Diego Cortes; Francisca Vicente; Olga Genilloud; Jose R Tormo; Fernando Peláez
Journal:  J Bioenerg Biomembr       Date:  2012-11-21       Impact factor: 2.945

2.  Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.

Authors:  Gordon J Florence; Andrew L Fraser; Eoin R Gould; Elizabeth F B King; Stefanie K Menzies; Joanne C Morris; Lindsay B Tulloch; Terry K Smith
Journal:  ChemMedChem       Date:  2014-08-21       Impact factor: 3.466

3.  Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells.

Authors:  Yong-Qiang Liu; Xin Cheng; Liang-Xia Guo; Chan Mao; Yi-Jie Chen; Hai-Xia Liu; Qi-Cai Xiao; Sheng Jiang; Zhu-Jun Yao; Guang-Biao Zhou
Journal:  PLoS One       Date:  2012-10-08       Impact factor: 3.240

4.  A minimalist NMR approach for the structural revision of mucoxin.

Authors:  Jun Yan; Atefeh Garzan; Radha S Narayan; Chrysoula Vasileiou; Babak Borhan
Journal:  Chemistry       Date:  2010-12-10       Impact factor: 5.236

5.  The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species.

Authors:  H R McLennan; M Degli Esposti
Journal:  J Bioenerg Biomembr       Date:  2000-04       Impact factor: 2.945

6.  Antifungal activity screening of fractions from Annona cherimola Mill. leaf extract against Fusarium oxysporum.

Authors:  Manuel Méndez-Chávez; Carlos A Ledesma-Escobar; Madeleine Hidalgo-Morales; Guadalupe Del Carmen Rodríguez-Jimenes; Victor José Robles-Olvera
Journal:  Arch Microbiol       Date:  2022-05-17       Impact factor: 2.552

7.  Synthesis and anti-tumor activity of carbohydrate analogues of the tetrahydrofuran containing acetogenins.

Authors:  Stewart Bachan; K A Tony; Akira Kawamura; Diego Montenegro; Anjali Joshi; Himanshu Garg; David R Mootoo
Journal:  Bioorg Med Chem       Date:  2013-08-29       Impact factor: 3.641

8.  Mitochondrial complex I inhibitors, acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway.

Authors:  Nuria de Pedro; Bastien Cautain; Angeles Melguizo; Francisca Vicente; Olga Genilloud; Fernando Peláez; Jose R Tormo
Journal:  J Bioenerg Biomembr       Date:  2012-11-21       Impact factor: 2.945

9.  Recent progress on the total synthesis of acetogenins from Annonaceae.

Authors:  Nianguang Li; Zhihao Shi; Yuping Tang; Jianwei Chen; Xiang Li
Journal:  Beilstein J Org Chem       Date:  2008-12-05       Impact factor: 2.883

Review 10.  An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill.

Authors:  Alexandra G Durán; M Teresa Gutiérrez; Francisco J R Mejías; José M G Molinillo; Francisco A Macías
Journal:  Molecules       Date:  2021-05-14       Impact factor: 4.411
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