Literature DB >> 8687469

Molecular cloning of the rat inducible nitric oxide synthase gene promoter.

W Eberhardt1, D Kunz, R Hummel, J Pfeilschifter.   

Abstract

The inducible nitric oxide synthase (iNOS) is not constitutively expressed but is induced in many types of mammalian cells by cytokines and bacterial endotoxins. Previously, we have reported the most interesting feature of rat iNOS gene that is up-regulated by cyclic AMP at transcriptional level as demonstrated by nuclear run-on assay. We now have isolated and sequenced the rat iNOS gene promoter and determined the transcription start site. Moreover, we have constructed a rat iNOS promoter-chloramphenicol acetyltransferase (CAT) fusion gene and analyzed its inducibility by interleukin 1 beta and cyclic AMP in transiently transfected Swiss 3T3 fibroblasts.

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Year:  1996        PMID： 8687469     DOI： 10.1006/bbrc.1996.0968

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

1.  Differential regulation of nitric oxide synthase mRNA expression by lipopolysaccharide and pro-inflammatory cytokines in fetal hepatocytes treated with cycloheximide.

Authors:  M Casado; M J Díaz-Guerra; L Boscá; P Martín-Sanz
Journal:  Biochem J       Date:  1997-11-01       Impact factor: 3.857

Review 2.  Oxidant Mechanisms in Renal Injury and Disease.

Authors:  Brian B Ratliff; Wasan Abdulmahdi; Rahul Pawar; Michael S Wolin
Journal:  Antioxid Redox Signal       Date:  2016-04-26       Impact factor: 8.401

3.  The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages.

Authors:  Daniela De Stefano; Maria Chiara Maiuri; Barbara Iovine; Armando Ialenti; Maria Assunta Bevilacqua; Rosa Carnuccio
Journal:  J Mol Med (Berl)       Date:  2005-11-12       Impact factor: 4.599

4.  Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.

Authors:  D Kunz; G Walker; W Eberhardt; U K Messmer; A Huwiler; J Pfeilschifter
Journal:  J Clin Invest       Date:  1997-12-01       Impact factor: 14.808

5.  Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis.

Authors:  Ahmed Aglan; Sebastian Longen; Nathalie Dehne; Yvette Köhler; Mohamed Hassan; Martina Beck; Claudia Tredup; Meike Boosen; Tzung-Harn Louise Hsieh; Liliana Schaefer; Karl-Friedrich Beck; Josef Pfeilschifter
Journal:  J Mol Med (Berl)       Date:  2017-01-04       Impact factor: 4.599

6.  Gliadin increases iNOS gene expression in interferon-gamma-stimulated RAW 264.7 cells through a mechanism involving NF-kappa B.

Authors:  Maria Chiara Maiuri; Daniela De Stefano; Guido Mele; Barbara Iovine; Maria Assunta Bevilacqua; Luigi Greco; Salvatore Auricchio; Rosa Carnuccio
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-07-04       Impact factor: 3.000

Review 7.  Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases.

Authors:  Roman Ginnan; Benjamin J Guikema; Katharine E Halligan; Harold A Singer; David Jourd'heuil
Journal:  Free Radic Biol Med       Date:  2008-01-22       Impact factor: 7.376

8.  Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1.

Authors:  Tomonaga Ichikawa; Jifeng Zhang; Kai Chen; Yusen Liu; Francisco J Schopfer; Paul R S Baker; Bruce A Freeman; Yuqing E Chen; Taixing Cui
Journal:  Endocrinology       Date:  2008-05-08       Impact factor: 4.736

9.  Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages.

Authors:  Ching-Wen Chen; Sho Tone Lee; Wen Tung Wu; Wen-Mei Fu; Feng-Ming Ho; Wan Wan Lin
Journal:  Br J Pharmacol       Date:  2003-10-06       Impact factor: 8.739

10.  Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy.

Authors:  Jaspreet Singh; Mushfiquddin Khan; Inderjit Singh
Journal:  J Lipid Res       Date:  2008-08-21       Impact factor: 5.922
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