BACKGROUND: The incidence of oral squamous cell carcinoma (OSCC) is on the increase in developing countries. MATERIALS AND METHODS: Formalin fixed paraffin embedded blocks of OSCCs from a Black South African population sample of peri-urban and rural origin were selected as follows: Group 1 - 57 OSCCs with a mean age of 59 years; Group 2 - 43 OSCCs all cases younger than 40 years; Group 3 - 46 OSCCs with blocks containing only tumour tissue without any normal epithelium and Group 4, a control group of 38 non-neoplastic epithelial lesions. Type specific primers were used in a standard PCR to amplify a segment of the E6 region of HPV 6, 11, 16 and 18. RESULTS: HPV 11 and 16 DNA were found in one sample each from groups 1 and 2 respectively. CONCLUSION: HPV is not an etiologic factor in the development of OSCC in the population studied.
BACKGROUND: The incidence of oral squamous cell carcinoma (OSCC) is on the increase in developing countries. MATERIALS AND METHODS:Formalin fixed paraffin embedded blocks of OSCCs from a Black South African population sample of peri-urban and rural origin were selected as follows: Group 1 - 57 OSCCs with a mean age of 59 years; Group 2 - 43 OSCCs all cases younger than 40 years; Group 3 - 46 OSCCs with blocks containing only tumour tissue without any normal epithelium and Group 4, a control group of 38 non-neoplastic epithelial lesions. Type specific primers were used in a standard PCR to amplify a segment of the E6 region of HPV 6, 11, 16 and 18. RESULTS:HPV 11 and 16 DNA were found in one sample each from groups 1 and 2 respectively. CONCLUSION: HPV is not an etiologic factor in the development of OSCC in the population studied.
Authors: Cherie Paquette; Mark F Evans; Shabnum S Meer; Vanitha Rajendran; Christine S-C Adamson; Kumarasen Cooper Journal: Head Neck Pathol Date: 2013-12
Authors: Neil H Wood; Koketso S Makua; Ramokone L Lebelo; Nina Redzic; Ina Benoy; Olivier M Vanderveken; Johannes Bogers Journal: Adv Virol Date: 2020-08-26
Authors: Emmanuel A Oga; Lisa M Schumaker; Biodun Sulyman Alabi; Darlington Obaseki; Aniefon Umana; Ima-Abasi Bassey; Godwin Ebughe; Olabode Oluwole; Teniola Akeredolu; Sally N Adebamowo; Patrick Dakum; Kevin Cullen; Clement A Adebamowo Journal: PLoS One Date: 2016-04-06 Impact factor: 3.240
Authors: Harshita B Mistry; Ramokone L Lebelo; Fulufhelo Matshonyonge; Maphoshane Nchabeleng; Matsontso Mathebula; John-Paul Bogers; Neil H Wood Journal: AIMS Public Health Date: 2021-12-03