Effects of selenium and vitamin E on the immune responses of domestic animals.

The gross effects of selenium and vitamin E deficiency on animal production and the potential benefits of supplementation are recognised, and the influence of these micronutrients on the resistance of animals to a variety of infections has also been reported. As a result, deficiencies could compromise the immune system and result in a decline in production and performance before gross effects become apparent. Data obtained by laboratories studying different animal species indicate that the responses of domestic animals, particularly ruminants, differ from those of human beings and laboratory animals as well as differing among themselves. This paper provides a comprehensive review of the effects of selenium and vitamin E on the immune responses of domestic animals and discusses their effects with respect to the differences in the basal nutritional status of the animals concerned, the type of supplements used, the route and timing of their administration and the different agents which have been used to stimulate an immune response.